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Jaime Martínez de Villarreal

dblp:370/5157 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2023
0000-0002-3003-7766ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › sequence analysis › read mapping
pseudoalignment
0.712023
Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data · Bioinform. 2023
Bioinformatics and computational biology › single-cell analysis
single-cell RNA sequencing
0.712023
Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data · Bioinform. 2023

Methods — techniques the papers use, named apart from their topics

pseudoalignment · 0.7
YearPublicationVenuePosition
2023 Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data
abstract
MOTIVATION: Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation mechanisms such as DNA methylation, histone modification and regulation by small RNAs. TE re-activation is associated with stemness potential acquisition, regulation of innate immunity and disease, such as cancer. However, the vast majority of current knowledge in the field is based on bulk expression studies, and very little is known on cell-type- or state-specific expression of TE-derived transcripts. Therefore, cost-efficient single-cell-resolution TE expression analytical approaches are needed. RESULTS: We have implemented an analytical approach based on pseudoalignment to consensus sequences to incorporate TE expression information to scRNAseq data. AVAILABILITY AND IMPLEMENTATION: All the data and code implemented are available as Supplementary data and in: https://github.com/jmzvillarreal/kallisto_TE_scRNAseq. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Jaime Martínez de Villarreal, Mark Kalisz, Gabriel Piedrafita, Osvaldo Graña, Dafni Chondronasiou, Manuel Serrano, Francisco X. Real
Bioinform.1