3D reassembly is a challenging spatial intelligence task with broad applications across scientific domains. While large-scale synthetic datasets have fueled promising learning-based approaches, their generalizability to different domains is limited. Critically, it remains uncertain whether models trained on synthetic datasets can generalize to real-world fractures where breakage patterns are more complex. To bridge this gap, we propose GARF, a generalizable 3D reassembly framework for real-world fractures. GARF leverages fracture-aware pretraining to learn fracture features from individual fragments, with flow matching enabling precise 6-DoF alignments. At inference time, we introduce one-step preassembly, improving robustness to unseen objects and varying numbers of fractures. In collaboration with archaeologists, paleoanthropologists, and ornithologists, we curate Fractura, a diverse dataset for vision and learning communities, featuring real-world fracture types across ceramics, bones, eggshells, and lithics. Comprehensive experiments have shown our approach consistently outperforms state-of-the-art methods on both synthetic and real-world datasets, achieving 82.87\% lower rotation error and 25.15\% higher part accuracy. This sheds light on training on synthetic data to advance real-world 3D puzzle solving, demonstrating its strong generalization across unseen object shapes and diverse fracture types. GARF's code, data and demo are available at https://ai4ce.github.io/GARF/.

Lithic Use-Wear Analysis (LUWA) using microscopic images is an underexplored vision-for-science research area. It seeks to distinguish the worked material, which is critical for understanding archaeological artifacts, material interactions, tool functionalities, and dental records. However, this challenging task goes beyond the well-studied image classification problem for common objects. It is affected by many confounders owing to the complex wear mechanism and microscopic imaging, which makes it difficult even for human experts to identify the worked material successfully. In this paper, we investigate the following three questions on this unique vision task for the first time:(i) How well can state-of-the-art pre-trained models (like DINOv2) generalize to the rarely seen domain? (ii) How can few-shot learning be exploited for scarce microscopic images? (iii) How do the ambiguous magnification and sensing modality influence the classification accuracy? To study these, we collaborated with archaeologists and built the first open-source and the largest LUWA dataset containing 23,130 microscopic images with different magnifications and sensing modalities. Extensive experiments show that existing pretrained models notably outperform human experts but still leave a large gap for improvements. Most importantly, the LUWA dataset provides an underexplored opportunity for vision and learning communities and complements existing image classification problems on common objects.