The Model Context Protocol (MCP) is rapidly emerging as a pivotal open standard, designed to enhance agent-tool integration and interoperability, and is positioned to unlock a new era of powerful, interconnected, and genuinely utilitarian agentic AI. However, despite MCP's growing adoption, existing benchmarks often fail to capture real-world agent performance within this new paradigm, leading to a distorted perception of their true operational value and an inability to reliably differentiate proficiencies. To bridge this critical evaluation gap, we introduce MCP-AgentBench—a comprehensive benchmark specifically engineered to rigorously assess language agent capabilities in MCP-mediated tool interactions. Core contributions of MCP-AgentBench include: the establishment of a robust MCP testbed comprising 33 operational servers with 188 distinct tools; the development of a benchmark featuring 600 systematically designed queries distributed across 6 distinct categories of varying interaction complexity; and the introduction of MCP-Eval, a novel outcome-oriented evaluation methodology prioritizing real-world task success. Through extensive empirical evaluation of leading language agents, we provide foundational insights. MCP-AgentBench aims to equip the research community with a standardized and reliable framework to build, validate, and advance agents capable of fully leveraging MCP's transformative benefits, thereby accelerating progress toward truly capable and interoperable AI systems.

While deep learning models play a crucial role in predicting antibody-antigen interactions (AAI), the scarcity of publicly available sequence-structure pairings constrains their generalization. Current AAI methods often focus on residue-level static details, overlooking fine-grained structural representations of antibodies and their inter-antibody similarities. To tackle this challenge, we introduce a multi-modality representation approach that integates 3D structural and 1D sequence data to unravel intricate intra-antibody hierarchical relationships. By harnessing these representations, we present MuLAAIP, an AAI prediction framework that utilizes graph attention networks to illuminate graph-level structural features and normalized adaptive graph convolution networks to capture inter-antibody sequence associations. Furthermore, we have curated an AAI benchmark dataset comprising both structural and sequence information along with interaction labels. Through extensive experiments on this benchmark, our results demonstrate that MuLAAIP outperforms current state-of-the-art methods in terms of predictive performance. The implementation code and dataset are publicly available at https://github.com/trashTian/MuLAAIP for reproducibility.

Complex tasks involving tool integration pose significant challenges for Large Language Models (LLMs), leading to the emergence of multi-agent workflows as a promising solution. Reflection has emerged as an effective strategy for correcting erroneous trajectories in agentic workflows. However, existing approaches only exploit such capability in the post-action stage, where the agent observes the execution outcomes. We argue that, like humans, LLMs can also engage in reflection before action execution: the agent can anticipate undesirable outcomes from its own decisions, which not only provides a necessarily complementary perspective to evaluate the decision but also prevents the propagation of errors throughout the trajectory. In this paper, we propose MIRROR, a framework that consists of both intra-reflection, which critically assesses intended actions before execution, and inter-reflection, which further adjusts the trajectory based on observations. This design systematically leverages LLM reflection capabilities to eliminate and rectify erroneous actions on a more comprehensive scope. Evaluations on both the StableToolBench and TravelPlanner benchmarks demonstrate MIRROR's superior performance, achieving state-of-the-art results compared to existing approaches.

Text style transfer (TST) is an important task in natural language generation, which aims to transfer the text style (e.g., sentiment) while keeping its semantic information.Due to the absence of parallel datasets for supervision, most existing studies have been conducted in an unsupervised manner, where the generated sentences often suffer from high semantic divergence and thus low semantic preservation.In this paper, we propose a novel disentanglementbased framework for TST named DisenTrans, where disentanglement means that we separate the attribute and content components in the natural language corpus and consider this task from these two perspectives.Concretely, we first create a disentangled Chain-of-Thought prompting procedure to synthesize parallel data and corresponding attribute components for supervision.Then we develop a disentanglement learning method with synthetic data, where two losses are designed to enhance the focus on attribute properties and constrain the semantic space, thereby benefiting style control and semantic preservation respectively.Instructed by the disentanglement concept, our framework creates valuable supervised information and utilizes it effectively in TST tasks.Extensive experiments on mainstream datasets present that our framework achieves significant performance with great sample efficiency.

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant approach for estimating the binding strength between drugs and target proteins. However, existing methods simply utilize the drug’s local information from molecular topology rather than global information. Additionally, the features of drugs and proteins are usually fused with a simple concatenation operation, limiting their effectiveness. To address these challenges, we proposed ViDTA, an enhanced DTA prediction framework. We introduce virtual nodes into the Graph Neural Network (GNN)-based drug feature extraction network, which acts as a global memory to exchange messages more efficiently. By incorporating virtual graph nodes, we seamlessly integrate local and global features of drug molecular structures, expanding the GNN’s receptive field. Additionally, we propose an attention-based linear feature fusion network for better capturing the interaction information between drugs and proteins. Experimental results evaluated on various benchmarks including Davis, Metz, and KIBA demonstrate that our proposed ViDTA outperforms the state-of-the-art baselines.

The effective detection of AI-generated text is a vital principle to ensure responsible use of large language models (LLMs). Previous studies mainly focused on discovering and utilizing internal evidences contained in the text itself to perform the detection, while ignoring external evidences implicated in an established knowledge graph (KG) which may also be key discriminative factors between AI-generated and human-written text. To address this deficiency, we propose IDEATE, a novel hierarchical graph network that utilizes both internal and external factual structures to detect AI-generated text. IDEATE consists of a mention-level subgraph at the bottom to describe internal factual structures of mentioned entities reflected in the input text, and an entity-level subgraph at the top to describe external factual structures of mentioned entities reflected in an external KG. Hierarchical graph convolution is then applied successively on the two subgraphs, through which the two types of factual structures will be embedded into the output and used for the final detection. Extensive experiments on four benchmarking datasets show that IDEATE consistently outperforms current state-of-the-art methods in detecting text generated by various LLMs, ranging from GPT-2 to the more powerful ChatGPT, verifying the necessity and superiority of introducing external evidences for AI-generated text detection.