Capsule endoscopes, predominantly serving diagnostic functions, provide lucid internal imagery but are devoid of surgical or therapeutic capabilities. Consequently, despite lesion detection, physicians frequently resort to traditional endoscopic or open surgical procedures for treatment, resulting in more complex, potentially risky interventions. To surmount these limitations, this study introduces a chained flexible capsule endoscope (FCE) design concept, specifically conceived to navigate the inherent volume constraints of capsule endoscopes whilst augmenting their therapeutic functionalities. The FCE’s distinctive flexibility originates from a conventional rotating joint design and the incision pattern in the flexible material. In vitro experiments validated the passive navigation ability of the FCE in rugged intestinal tracts. Further, the FCE demonstrates consistent reptile-like peristalsis under the influence of an external magnetic field, and possesses the capability for film expansion and disintegration under high-frequency electromagnetic stimulation. These findings illuminate a promising path toward amplifying the therapeutic capacities of capsule endoscopes without necessitating a size compromise.

Helicobacter pylori, a pervasive bacterial infection associated with gastrointestinal disorders such as gastritis, peptic ulcer disease, and gastric cancer, impacts approximately 50% of the global population. The efficacy of standard clinical eradication therapies is diminishing due to the rise of antibiotic-resistant strains, necessitating alternative treatment strategies. Photodynamic therapy (PDT) emerges as a promising prospect in this context. This study presents the development and implementation of a magnetically-guided origami robot, incorporating flexible printed circuit units for sustained and stable phototherapy of Helicobacter pylori. Each integrated unit is equipped with wireless charging capabilities, producing an optimal power output that can concurrently illuminate up to 15 LEDs at their maximum intensity. Crucially, these units can be remotely manipulated via a magnetic field, facilitating both translational and rotational movements. We propose an open-loop manual control sequence that allows the formation of a stable, compliant triangular structure through the interaction of internal magnets. This adaptable configuration is uniquely designed to withstand the dynamic squeezing environment prevalent in real-world gastric applications. The research herein represents a significant stride in leveraging technology for innovative medical solutions, particularly in the management of antibiotic-resistant Helicobacter pylori infections.