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Oliver M. Turnbull

dblp:379/7676 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2024
0000-0002-0239-1207ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › protein design
antibody design
0.812024
p-IgGen: a paired antibody generative language model · Bioinform. 2024
Bioinformatics and computational biology
protein design
0.812024
p-IgGen: a paired antibody generative language model · Bioinform. 2024

Methods — techniques the papers use, named apart from their topics

protein language model · 0.8generative language model · 0.8fine-tuning · 0.8
YearPublicationVenuePosition
2024 p-IgGen: a paired antibody generative language model
abstract
SUMMARY: A key challenge in antibody drug discovery is designing novel sequences that are free from developability issues-such as aggregation, polyspecificity, poor expression, or low solubility. Here, we present p-IgGen, a protein language model for paired heavy-light chain antibody generation. The model generates diverse, antibody-like sequences with pairing properties found in natural antibodies. We also create a finetuned version of p-IgGen that biases the model to generate antibodies with 3D biophysical properties that fall within distributions seen in clinical-stage therapeutic antibodies. AVAILABILITY AND IMPLEMENTATION: The model and inference code are freely available at www.github.com/oxpig/p-IgGen. Cleaned training data are deposited at doi.org/10.5281/zenodo.13880874.
Oliver M. Turnbull, Dino Oglic, Rebecca Croasdale-Wood, Charlotte M. Deane
Bioinform.1