Synthesizing medical images remains challenging due to limited annotated pathological data, modality domain gaps, and the complexity of representing diffuse pathologies such as liver cirrhosis. Existing methods often struggle to maintain anatomical fidelity while accurately modeling pathological features, frequently relying on priors derived from natural images or inefficient multi-step sampling. In this work, we introduce ViCTr (Vital Consistency Transfer), a novel two-stage framework that combines a rectified flow trajectory with a Tweedie-corrected diffusion process to achieve high-fidelity, pathology-aware image synthesis. First, we pretrain ViCTr on the ATLAS-8k dataset using Elastic Weight Consolidation (EWC) to preserve critical anatomical structures. We then fine-tune the model adversarially with Low-Rank Adaptation (LoRA) modules for precise control over pathology severity. By reformulating Tweedie's formula within a linear trajectory framework, ViCTr supports one-step sampling, reducing inference from 50 steps to just 4, without sacrificing anatomical realism. We evaluate ViCTr on BTCV (CT), AMOS (MRI), and CirrMRI600+ (cirrhosis) datasets. Results demonstrate state-of-the-art performance, achieving a Medical Frechet Inception Distance (MFID) of 17.01 for cirrhosis synthesis 28% lower than existing approaches and improving nnUNet segmentation by +3.8% mDSC when used for data augmentation. Radiologist reviews indicate that ViCTr-generated liver cirrhosis MRIs are clinically indistinguishable from real scans. To our knowledge, ViCTr is the first method to provide fine-grained, pathology-aware MRI synthesis with graded severity control, closing a critical gap in AI-driven medical imaging research.

The interaction between deep brain stimulation (DBS) systems and magnetic resonance imaging (MRI) can induce tissue heating in patients. While electromagnetic (EM) simulations can be used to estimate the specific absorption rate (SAR) values in the presence of an implanted DBS system, they are computationally expensive. To address this drawback, we predict local SAR values in the tips of DBS leads with machine learning based efficient algorithms, specifically XgBoost and deep learning. We significantly outperformed the previous state of the art, and adapted new machine learning models based on Residual Networks family as well as XgBoost models. We observed that already extracted limited features are better suited for ensemble learning via XgBoost than deep networks due the small-data regime. Although we conclude that boosting gradient algorithm is more suitable for this non-linear regression problem due to structured nature of the data and small data regime, we found that width plays a more critical role than depth in network design and it has a strong potential for future research. Our experimental results, using a dataset of 260 instances that are patient-derived and artificial, reached an outstanding RMSE of 17.8 W/kg with XgBoost, 78 W/kg with deep networks, given that the previous study on this problem reached a state-of-the-art root mean square error value (RMSE) of 168 W/kg.