While machine learning shows promise in automated knowledge generation, current techniques such as large language models and micro-targeted influence operations can be exploited for harmful purposes like the proliferation of disinformation. The European Union’s Digital Services Act (DSA) is an exemplary policy response addressing these harms generated by online platforms. In this regard, it necessitates a comprehensive evaluation of its impact on curbing the harmful downstream effects of these opaque practices. Despite their harmful applications, we argue that machine learning techniques offer immense, yet under-exploited, potential for unraveling the impacts of regulations like the DSA. Following an analysis that reveals possible limitations in the DSA’s provisions, we call for resolute efforts to address methodological barriers around appropriate data access, isolating marginal regulatory effects, and facilitating generalization across different contexts. Given the identified advantages of data-driven approaches to regulatory delivery, we advocate for machine learning research to help quantify the policy impacts on online harms.