Bridging the gap between high-level algorithm development and efficient FPGA implementation remains a fundamental challenge, particularly in latency- and resource-constrained domains such as wireless communications. In practice, many signal processing and communication algorithms are first developed and validated at the software level, where rapid iteration and numerical flexibility are critical, making MATLAB a de facto environment for algorithm prototyping and verification. To deploy these algorithms on FPGA platforms, High-Level Synthesis (HLS) is commonly adopted as an intermediate step that enables hardware generation from high-level descriptions. Although HLS significantly improves productivity compared with register-transfer level design, translating MATLAB models into high-quality HLS implementations still requires substantial manual effort and deep domain expertise. Designers must carefully restructure computation patterns, redesign dataflows, and tune synthesis parameters to meet strict performance and resource constraints. Recent advances in large language models (LLMs) suggest a promising direction for automating this translation process. However, current LLM-based approaches remain unreliable in complex hardware design workflows, as they suffer from hallucinations, forgetting, limited domain expertise, and often overlook key performance metrics such as latency, throughput, and resource utilization.

MOTIVATION: DNA methylation at cytosine-phosphate-guanine (CpG) sites is one of the most important epigenetic markers. Therefore, epidemiologists are interested in investigating DNA methylation in large cohorts through epigenome-wide association studies (EWAS). However, the observed EWAS data are bulk data with signals aggregated from distinct cell types. Deconvolution of cell-type-specific signals from EWAS data is challenging because phenotypes can affect both cell-type proportions and cell-type-specific methylation levels. Recently, there has been active research on detecting cell-type-specific risk CpG sites for EWAS data. However, existing methods all assume that the methylation levels of different CpG sites are independent and perform association detection for each CpG site separately. Although these methods significantly improve the detection at the aggregated-level-identifying a CpG site as a risk CpG site as long as it is associated with the phenotype in any cell type, they have low power in detecting cell-type-specific associations for EWAS with typical sample sizes. RESULTS: Here, we develop a new method, Fine-scale inference for Differentially Methylated Regions (FineDMR), to borrow strengths of nearby CpG sites to improve the cell-type-specific association detection. Via a Bayesian hierarchical model built upon Gaussian process functional regression, FineDMR takes advantage of the spatial dependencies between CpG sites. FineDMR can provide cell-type-specific association detection as well as output subject-specific and cell-type-specific methylation profiles for each subject. Simulation studies and real data analysis show that FineDMR substantially improves the power in detecting cell-type-specific associations for EWAS data. AVAILABILITY AND IMPLEMENTATION: FineDMR is freely available at https://github.com/JiaRuofan/Detection-of-Cell-type-specific-DMRs-in-EWAS.

In practical object detection scenarios, distributed data and stringent privacy protections significantly limit the feasibility of traditional centralized training methods. Federated learning (FL) emerges as a promising solution to this dilemma. Nonetheless, the issue of data heterogeneity introduces distinct challenges to federated object detection, evident in diminished object perception, classification and localization abilities. In response, we introduce a task-driven federated learning methodology, dubbed Adaptive Hierarchical Aggregation (FedAHA), tailored to overcome these obstacles. Our algorithm unfolds in two strategic phases from shallow-to-deep layers: (1) Structure-aware Aggregation (SAA) aligns feature extractors during the aggregation phase, thus bolstering the global model's object perception capabilities; (2) Convex Semantic Calibration (CSC) leverages convex function theory to average semantic features instead of model parameters, enhancing the global model's classification and localization precision. We demonstrate experimentally and theoretically the effectiveness of the proposed two modules respectively. Our method consistently outperforming the state-of-the-art methods across multiple valuable application scenarios from 2.26% to 7.61%. Moreover, we build a real FL system using Raspberry Pis to demonstrate that our approach achieves a good trade-off between performance and efficiency.