Large Language Model (LLM)-based multi-agent systems show promise for automating real-world tasks but struggle to transfer across domains due to their domain-specific nature. Current approaches face two critical shortcomings: they require complete architectural redesign and full retraining of all components when applied to new domains. We introduce **Workforce**, a hierarchical multi-agent framework that decouples strategic planning from specialized execution through a modular architecture comprising: *(i)* a *domain-agnostic* **Planner** for task decomposition, *(ii)* a **Coordinator** for subtask management, and *(iii)* specialized **Workers** with *domain-specific* tool-calling capabilities. This decoupling enables cross-domain transferability during both inference and training phases: During inference, Workforce seamlessly adapts to new domains by adding or modifying worker agents; For training, we introduce **Optimized Workforce Learning (OWL)**, which improves generalization across domains by optimizing a domain-agnostic planner with reinforcement learning from real-world feedback. To validate our approach, we evaluate Workforce on the GAIA benchmark, covering various realistic, multi-domain agentic tasks. Experimental results demonstrate Workforce achieves open-source state-of-the-art performance (**69.70%**), outperforming commercial systems like OpenAI's Deep Research by **2.34%**. More notably, our OWL-trained 32B model achieves **52.73%** accuracy (**+16.37%**) and demonstrates performance comparable to GPT-4o on challenging tasks. To summarize, by enabling scalable generalization and modular domain transfer, our work establishes a foundation for the next generation of general-purpose AI assistants. *Our code is available at [Anonymous URL](https://anonymous.4open.science/r/annonymous-owl/), and our data is available at [Anonymous URL](https://huggingface.co/anonymous21016).*