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Roman Klypa

dblp:401/0291 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2025
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Artificial intelligence
1 paper
Generative modeling · 100%
Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Machine learning › Generative modeling › diffusion model
conditional generation
0.912025
BAnG: Bidirectional Anchored Generation for Conditional RNA Design · ICML 2025
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA design
0.912025
BAnG: Bidirectional Anchored Generation for Conditional RNA Design · ICML 2025

Methods — techniques the papers use, named apart from their topics

deep learning · 1.7bidirectional anchored generation · 1.7
YearPublicationVenuePosition
2025 BAnG: Bidirectional Anchored Generation for Conditional RNA Design
abstract
Designing RNA molecules that interact with specific proteins is a critical challenge in experimental and computational biology. Existing computational approaches require a substantial amount of experimentally determined RNA sequences for each specific protein or a detailed knowledge of RNA structure, restricting their utility in practice. To address this limitation, we develop RNA-BAnG, a deep learning-based model designed to generate RNA sequences for protein interactions without these requirements. Central to our approach is a novel generative method, Bidirectional Anchored Generation (BAnG), which leverages the observation that protein-binding RNA sequences often contain functional binding motifs embedded within broader sequence contexts. We first validate our method on generic synthetic tasks involving similar localized motifs to those appearing in RNAs, demonstrating its benefits over existing generative approaches. We then evaluate our model on biological sequences, showing its effectiveness for conditional RNA sequence design given a binding protein.
Roman Klypa, Alberto Bietti, Sergei Grudinin
ICML1