Reliable electronics plays a major role in shaping our daily lives, being a key enabler for critical applications, such as space missions, avionics, automotive, medicine, banking, automated industry, wireless communication networks, etc. However, design of highly reliable electronic systems remains a challenge with the advances in semiconductor technology and increase in integrated circuit (IC) complexity. In this work, we introduce the Horizon Europe Twinning project TWIN-RELECT, aimed at strengthening the scientific expertise in designing reliable integrated circuits. The paper presents the general project concept and objectives, and main directions of the joint research activities. The primary scientific goal is to contribute to the development of novel, more efficient, European Electronic Design Automation (EDA) tool-chain for design of reliable chips.