The design of a scalable Quantum Control Architecture (QCA) faces two primary challenges.First, the continuous growth in qubit counts has rendered distributed QCA inevitable, yet the nondeterministic latencies inherent in feedback loops demand cycleaccurate synchronization across multiple controllers.Existing synchronization strategies -whether lock-step or demand-drivenintroduce significant performance penalties.Second, existing quantum instruction set architectures are polarized, being either too abstract or too granular.This lack of a unifying design necessitates recurrent hardware customization for each new control requirement, which limits the system's reconfigurability and impedes the path toward a scalable and unified digital microarchitecture.Addressing these challenges, we propose Distributed-HISQ, featuring: (i) HISQ, A universal instruction set that redefines quantum control with a hardware-agnostic design.By decoupling from quantum operation semantics, HISQ provides a unified language for control sequences, enabling a single microarchitecture to support various control methods and enhancing system reconfigurability.(ii) BISP, a booking-based synchronization protocol that can potentially achieve zero-cycle synchronization overhead.The feasibility and adaptability of Distributed-HISQ are validated through its implementation on a commercial quantum control system targeting superconducting qubits.We performed a comprehensive evaluation using a customized quantum software stack.Our results show that BISP effectively synchronizes multiple control boards, leading to a 22.8% reduction in average program execution time and a ∼ 5× reduction in infidelity when compared to an existing lock-step synchronization scheme.