Demo Data from EDBT 2026 / reviewers in the wild / expert
Antoine Claessens
dblp:419/9533
· DBLP profile ↗
1ranked-venue papers
0as first author
1since 2021 · last 2025
0000-0002-4277-0914ORCID · reported
Domains — the database's venue-derived domains; a paper can count in several
Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021
Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.
| Interdisciplinary, comprehensive, and emerging computing
1 paper |
Bioinformatics and computational biology · 100% |
Topics — the 4 heaviest of 4, each with the papers that count most for it
| Topic | Weight | Papers | Last | Evidence papers |
|---|---|---|---|---|
Bioinformatics and computational biology › comparative genomics › orthology analysis
ortholog identification |
0.9 | 1 | 2025 | Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025 |
Bioinformatics and computational biology › protein sequence analysis
protein homology detection |
0.9 | 1 | 2025 | Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025 |
Bioinformatics and computational biology › protein analysis › protein bioinformatics › protein representation learning
protein language model embedding |
0.9 | 1 | 2025 | Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025 |
Bioinformatics and computational biology › protein analysis › protein bioinformatics
protein representation learning |
0.9 | 1 | 2025 | Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025 |
Methods — techniques the papers use, named apart from their topics
large language model · 0.9k-means clustering · 0.9
| Year | Publication | Venue | Position |
|---|---|---|---|
| 2025 | Exploring homology detection via k-means clustering of proteins embedded with a large language modelabstractMOTIVATION: Inferring protein homology from sequence information is essential for understanding species evolution and enabling functional annotation transfer. Besides similarity-based methods, several machine learning approaches have been developed using various ways of representing protein data. RESULTS: Here, we represent proteins with a biologically oriented large language model and apply k-means clustering to the embedded data to extract homology relationships. Although our approach lacks the sensitivity of other tools, we obtain better precision for the detection of n:m orthologs. Furthermore, we successfully reconstruct full orthologous groups from scratch, highlighting the growing potential of using large language models in combination with clustering algorithms for the analysis of protein data. AVAILABILITY AND IMPLEMENTATION: Datasets are available on OrthoMCL-DB as indicated in the Methods. Source code is available on GitHub at https://github.com/ThomasGTHB/OrthoLM and Zenodo at https://doi.org/10.5281/zenodo.16640170. Thomas Minotto, Antoine Claessens, Thomas D. Otto |
Bioinform. | 2 |