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Jan Pielesiak

dblp:420/9463 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2025
—ORCID · unresolved

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics › RNA structure prediction
consensus secondary structure
0.912025
RNAtive to recognize native-like structure in a set of RNA 3D models · Bioinform. 2025
Bioinformatics and computational biology › structural bioinformatics › nucleic acid structure analysis
RNA 3D structure
0.912025
RNAtive to recognize native-like structure in a set of RNA 3D models · Bioinform. 2025
Bioinformatics and computational biology
structural bioinformatics
0.912025
RNAtive to recognize native-like structure in a set of RNA 3D models · Bioinform. 2025

Methods — techniques the papers use, named apart from their topics

fuzzy set interaction networks · 0.9consensus-derived secondary structure · 0.9binary classification scoring · 0.9
YearPublicationVenuePosition
2025 RNAtive to recognize native-like structure in a set of RNA 3D models
abstract
MOTIVATION: Most widely used methods for evaluating RNA 3D structure models require experimental reference structures, which restricts their use for novel RNAs. They also often overlook recurrent structural features shared across multiple predictions of the same sequence. Although consensus approaches have proven effective in RNA sequence analysis and evolutionary studies, no existing tool applies these principles to evaluate ensembles of 3D models. This gap hampers the identification of native-like folds in computational predictions, particularly as AI-driven methods become increasingly prevalent. RESULTS: This paper presents RNAtive, the first computational tool to apply consensus-derived secondary structures for reference-free evaluation of RNA 3D models. RNAtive aggregates recurrent base-pairing and stacking interactions across ensembles of predicted 3D structures to construct a consensus secondary structure. It introduces a novel conditionally weighted consensus mode that treats interaction networks as fuzzy sets and uniquely allows integration of user-defined 2D structural constraints, enabling evaluation guided by experimental data. Input RNA models are ranked using two adapted binary-classification-based scores. Benchmarking against CASP15 competition data shows that models consistent with the consensus exhibit native-like structural features. The RNAtive web server offers an intuitive platform for comparing and prioritizing RNA 3D predictions, providing a scalable solution to address the variability inherent in deep learning and fragment-assembly methods. By bridging consensus principles with 3D structural analysis, RNAtive advances the exploration of RNA conformational landscapes and has potential applications in fields like therapeutic RNA design. AVAILABILITY: RNAtive is a freely accessible web server with a modern, user-friendly interface, available for scientific, educational, and commercial use at https://rnative.cs.put.poznan.pl/.
Jan Pielesiak, Maciej Antczak, Marta Szachniuk, Tomasz Zok
Bioinform.1