As cloud storage is extensively utilized in the contemporary digital age, assuring data integrity and conserving cloud storage space has become a priority for all. However, existing cross-user deduplication audit schemes conflict with the pay-as-you-go model, causing unnecessary costs and violating data isolation. Moreover, retaining a single copy of identical data across multiple users introduces maintenance challenges during data operations. To address these issues, we propose a new blockchain-enabled efficient deduplication and mixed auditing scheme which intricately integrates Message-Locked Encryption (MLE) to construct Homomorphic Verifiable Tags (HVTs), enabling deduplication without exposing confidential data. Our scheme supports single-user deduplication at both block and file levels, as well as plaintext-ciphertext mixed auditing, thereby preventing redundant payments while preserving data isolation to simplify maintenance during data operations and ownership transfers. By employing Elliptic Curve Cryptography (ECC) to encrypt keys and storing the encrypted keys on the blockchain, we ensure data confidentiality while reducing the burden of local key management. Leveraging blockchain-based smart contracts, we further design a self-auditing mechanism that eliminates reliance on trusted third-party auditors. Moreover, our scheme embraces dynamic data operations through an optimized Merkle Hash Tree (MHT) and enables secure cloud data ownership transfer via identity verification. Finally, we prove the correctness and security of our scheme and evaluate its performance through experiments and comparisons with state-of-the-art works, demonstrating its efficiency, particularly in the data upload phase.