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Daniel P. Lewinsohn

dblp:425/2532 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2023
0000-0002-4868-7847ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 67% Computational science and engineering · 33%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › single-cell analysis
cell type annotation
0.712023
Consensus label propagation with graph convolutional networks for single-cell RNA sequencing cell type annotation · Bioinform. 2023
Computational science and engineering › graph learning › graph neural network
graph convolutional network
0.712023
Consensus label propagation with graph convolutional networks for single-cell RNA sequencing cell type annotation · Bioinform. 2023
Bioinformatics and computational biology › single-cell analysis
single-cell RNA sequencing
0.712023
Consensus label propagation with graph convolutional networks for single-cell RNA sequencing cell type annotation · Bioinform. 2023

Methods — techniques the papers use, named apart from their topics

semi-supervised learning · 0.7graph convolutional network · 0.7consensus labeling · 0.7
YearPublicationVenuePosition
2023 Consensus label propagation with graph convolutional networks for single-cell RNA sequencing cell type annotation
abstract
MOTIVATION: Single-cell RNA sequencing (scRNA-seq) data, annotated by cell type, is useful in a variety of downstream biological applications, such as profiling gene expression at the single-cell level. However, manually assigning these annotations with known marker genes is both time-consuming and subjective. RESULTS: We present a Graph Convolutional Network (GCN)-based approach to automate the annotation process. Our process builds upon existing labeling approaches, using state-of-the-art tools to find cells with highly confident label assignments through consensus and spreading these confident labels with a semi-supervised GCN. Using simulated data and two scRNA-seq datasets from different tissues, we show that our method improves accuracy over a simple consensus algorithm and the average of the underlying tools. We also compare our method to a nonparametric neighbor majority approach, showing comparable results. We then demonstrate that our GCN method allows for feature interpretation, identifying important genes for cell type classification. We present our completed pipeline, written in PyTorch, as an end-to-end tool for automating and interpreting the classification of scRNA-seq data. AVAILABILITY AND IMPLEMENTATION: Our code for conducting the experiments in this paper and using our model is available at https://github.com/lewinsohndp/scSHARP.
Daniel P. Lewinsohn, Katinka A Vigh-Conrad, Donald F. Conrad, Cory B. Scott
Bioinform.1