We present Causal Active Inference with Real-time Interventions (CAIRN), a framework that models enterprise telemetry as a probabilistic causal graph and performs real-time Bayesian inference to estimate likely attack causes behind observed anomalies. When evidence is ambiguous, CAIRN triggers targeted interventions (e.g., decoy services, temporary isolation, or focused probes) to produce discriminative observations and reduce uncertainty. This closes the loop between detection and response: CAIRN tests competing hypotheses instead of flooding analysts with correlation-only alerts. In a testbed evaluation, CAIRN reduces false alarms and confirms attacks faster than a passive IDS baseline while maintaining low operational overhead.

In recent years, predicting driver's focus of attention has been a very active area of research in the autonomous driving community. Unfortunately, existing state-of-the-art techniques achieve this by relying only on human gaze information, thereby ignoring scene semantics. We propose a novel Semantics Augmented GazE (SAGE) detection approach that captures driving specific contextual information, in addition to the raw gaze. Such a combined attention mechanism serves as a powerful tool to focus on the relevant regions in an image frame in order to make driving both safe and efficient. Using this, we design a complete saliency prediction framework - SAGE-Net, which modifies the initial prediction from SAGE by taking into account vital aspects such as distance to objects (depth), ego vehicle speed, and pedestrian crossing intent. Exhaustive experiments conducted through four popular saliency algorithms show that on 49/56 (87.5%) cases - considering both the overall dataset and crucial driving scenarios, SAGE outperforms existing techniques without any additional computational overhead during the training process. The augmented dataset along with the relevant code are available as part of the supplementary material.

From computational simulations of a serotonin 2A receptor (5-HT(2A)R) model complexed with pharmacologically and structurally diverse ligands we identify different conformational states and dynamics adopted by the receptor bound to the full agonist 5-HT, the partial agonist LSD, and the inverse agonist Ketanserin. The results from the unbiased all-atom molecular dynamics (MD) simulations show that the three ligands affect differently the known GPCR activation elements including the toggle switch at W6.48, the changes in the ionic lock between E6.30 and R3.50 of the DRY motif in TM3, and the dynamics of the NPxxY motif in TM7. The computational results uncover a sequence of steps connecting these experimentally-identified elements of GPCR activation. The differences among the properties of the receptor molecule interacting with the ligands correlate with their distinct pharmacological properties. Combining these results with quantitative analysis of membrane deformation obtained with our new method (Mondal et al, Biophysical Journal 2011), we show that distinct conformational rearrangements produced by the three ligands also elicit different responses in the surrounding membrane. The differential reorganization of the receptor environment is reflected in (i)-the involvement of cholesterol in the activation of the 5-HT(2A)R, and (ii)-different extents and patterns of membrane deformations. These findings are discussed in the context of their likely functional consequences and a predicted mechanism of ligand-specific GPCR oligomerization.