Human well-being is inseparable from environmental context, with nature long recognized for its restorative potential. As everyday life becomes increasingly mediated by technology, access to nature is reconfigured through digital media. Virtual nature is often proposed as a tool for supporting well-being, yet the assumptions guiding its design and evaluation remain under-examined. This paper presents a systematic review of 124 empirical studies on virtual nature and well-being. Results generally trend toward clear positive effects on well-being; however, the current state-of-the-art remains considerably limited. Research is dominated by short-term, passive interventions grounded in stress reduction and attention restoration theories, prioritizing affective and physiological outcomes over cognitive or relational dimensions. We conclude by outlining four design inspirations that reposition virtual nature within HCI, shifting attention from short-term relief toward more diverse forms of human–nature interaction including cultural, participatory, and more-than-human perspectives.