Ruifeng Yuan, Chaohao Yuan, David Dai, Yu Rong, Hong Cheng, Hou Pong Chan, Chenghao Xiao. Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2026.

Clinical decision‑making routinely demands reasoning over heterogeneous data, yet existing multimodal language models (MLLMs) remain largely vision‑centric and fail to generalize across clinical specialties. To bridge this gap, we introduce QoQ-Med-7B/32B, the first open generalist clinical foundation model that jointly reasons across medical images, time‑series signals, and text reports. QoQ-Med is trained with Domain‑aware Relative Policy Optimization (DRPO), a novel reinforcement‑learning objective that hierarchically scales normalized rewards according to domain rarity and modality difficulty, mitigating performance imbalance caused by skewed clinical data distributions. Trained on 2.61 million instruction tuning pairs spanning 9 clinical domains, we show that DRPO training boosts diagnostic performance by 43% in macro‑F1 on average across all visual domains as compared to other critic-free training methods like GRPO. Furthermore, with QoQ-Med trained on intensive segmentation data, it is able to highlight salient regions related to the diagnosis, with an IoU 10x higher than open models while reaching the performance of OpenAI o4-mini. To foster reproducibility and downstream research, we release (i) the full model weights, (ii) the modular training pipeline, and (iii) all intermediate reasoning traces.

Advances in software-defined networking (SDN) enable a wave of innovation in a wide selection of networks ranging from data center networks to WAN. While existing standard bodies for mobile networks define stringent requirements, they too are embracing the flexibility of SDN in defining the specifications of the next generation of mobile networks. Mobile edge computing (MEC), in particular, is an emerging architecture to bring virtualized network functions and programmable network devices closer to the user. For instance, delay-sensitive or bandwidth-hungry computing resources are moved to the edge of the radio access network (RAN) to provide low latency computation and/or content for users while alleviating the backhaul pressure for network operators. In this paper, we propose an edge gateway (EGW) in the MEC that enables offloading of computation and storage resources to the edge of mobile networks. The EGW is backward compatible with components and protocols of LTE networks and does not require any modification in the user equipment, LTE software, or offloaded resources. We have designed and implemented the EGW using P4 language and verified its operation on a small testbed using a low-end P4 target and a reference LTE protocol stack.

360° video streaming is a key component of the emerging Virtual Reality (VR) and Augmented Reality (AR) applications. In 360° video streaming, a user may freely navigate through the captured 360° video scene by changing her desired Field-of-View. High-throughput and low-delay data transfers enabled by 5G wireless networks can potentially facilitate untethered 360° video streaming experience. Meanwhile, the high volatility of 5G wireless links present unprecedented challenges for smooth 360° video streaming. In this paper, novel multi-path multi-tier 360° video streaming solutions are developed to simultaneously address the dynamics in both network bandwidth and user viewing direction. We systematically investigate various design trade-offs on streaming quality and robustness. Through simulations driven by real 5G network bandwidth traces and user viewing direction traces, we demonstrate that the proposed 360° video streaming solutions can achieve a high-level of Quality-of-Experience (QoE) in the challenging 5G wireless network environment.

Cancer metabolism has received renewed interest as a potential target for cancer therapy. In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg effect, the reverse Warburg effect and glutamine addiction. At the intracellular level, we construct a network of central metabolism and perform flux balance analysis (FBA) to estimate metabolic fluxes; at the cellular level, we exploit this metabolic network to calculate parameters for a coarse-grained description of cellular growth kinetics; and at the multicellular level, we incorporate these kinetic schemes into the cellular automata of an agent-based model (ABM), iDynoMiCS. This ABM evaluates the reaction-diffusion of the metabolites, cellular division and motion over a simulation domain. Our multi-scale simulations suggest that the Warburg effect provides a growth advantage to the tumor cells under resource limitation. However, we identify a non-monotonic dependence of growth rate on the strength of glycolytic pathway. On the other hand, the reverse Warburg scenario provides an initial growth advantage in tumors that originate deeper in the tissue. The metabolic profile of stromal cells considered in this scenario allows more oxygen to reach the tumor cells in the deeper tissue and thus promotes tumor growth at earlier stages. Lastly, we suggest that glutamine addiction does not confer a selective advantage to tumor growth with glutamine acting as a carbon source in the tricarboxylic acid (TCA) cycle, any advantage of glutamine uptake must come through other pathways not included in our model (e.g., as a nitrogen donor). Our analysis illustrates the importance of accounting explicitly for spatial and temporal evolution of tumor microenvironment in the interpretation of metabolic scenarios and hence provides a basis for further studies, including evaluation of specific therapeutic strategies that target metabolism.