Zhendong Zhao

dblp:46/6153 · DBLP profile ↗
← Back
34ranked-venue papers
6as first author
26since 2021 · last 2026
—ORCID · conflict

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 19 · 3 first-author · 16 since 2021Graphics, computer vision, multimedia, augmented reality and games · 14 · 2 first-author · 11 since 2021Databases, data management, data science and information retrieval · 5 · 1 first-author · 5 since 2021Computer networks · 3 · 3 since 2021Applied, interdisciplinary, general and emerging computing · 2 · 1 first-author
YearPublicationVenuePosition
2026 ARGH-Mark: Anchor-Synchronized Watermarking with Hamming Correction for Robust and Quality-Preserving LLM Attribution
abstract
The proliferation of large language models has intensified demands for reliable content attribution, yet existing watermarking techniques face a fundamental trilemma: they cannot simultaneously optimize for robustness against attacks, minimal text quality degradation, and detection efficiency. To resolve this challenge, we propose ARGH-Mark, a novel watermarking framework that integrates three synergistic innovations: (1) Anchor-synchronized phase recovery for maintaining detection integrity under insertion/deletion attacks, (2) RG-balanced vocabulary modulation that dynamically partitions lexicons via contextual hashing to preserve generation quality, and (3) Hamming-based error correction enabling single-bit error rectification through algebraic coding. Comprehensive evaluations across question answering (ELI5), summarization (CNN/DailyMail), and text generation (C4) demonstrate state-of-the-art performance: the proposed ARGH-Mark framework achieves near-perfect match rate and bit accuracy across diverse configurations, while preserving the quality of the generated text. It significantly reduces detection latency, enabling real-time extraction, and maintains high robustness against token tampering attacks through integrated Hamming error correction, ensuring reliable attribution in adversarial settings. ARGH-Mark achieves a new Pareto frontier in the watermarking design space and advances trustworthy deployment of generative AI in alignment-critical applications.
He Li 0010, Xiaojun Chen 0004, Jingcheng He, Zhendong Zhao, Shuguang Yuan 0003, Yunfei Yang 0001
AAAI4
2026 DeepTracer: Tracing Stolen Model via Deep Coupled Watermarks
abstract
Model watermarking techniques can embed watermark information into the protected model for ownership declaration by constructing specific input-output pairs. However, existing watermarks are easily removed when facing model stealing attacks, and make it difficult for model owners to effectively verify the copyright of stolen models. In this paper, we analyze the root cause of the failure of current watermarking methods under model stealing scenarios and then explore potential solutions. Specifically, we introduce a robust watermarking framework, DeepTracer, which leverages a novel watermark samples construction method and a same-class coupling loss constraint. DeepTracer can incur a high-coupling model between watermark task and primary task that makes adversaries inevitably learn the hidden watermark task when stealing the primary task functionality. Furthermore, we propose an effective watermark samples filtering mechanism that elaborately select watermark key samples used in model ownership verification to enhance the reliability of watermarks. Extensive experiments across multiple datasets and models demonstrate that our method surpasses existing approaches in defending against various model stealing attacks, as well as watermark attacks, and achieves new state-of-the-art effectiveness and robustness.
Yunfei Yang 0001, Xiaojun Chen 0004, Yuexin Xuan, Zhendong Zhao, He Li 0010
AAAI4
2026 Value-Aligned Prompt Moderation via Zero-Shot Agentic Rewriting for Safe Image Generation
abstract
Generative vision-language models like Stable Diffusion demonstrate remarkable capabilities in creative media synthesis, but they also pose substantial risks of producing unsafe, offensive, or culturally inappropriate content when prompted adversarially. Current defenses struggle to align outputs with human values without sacrificing generation quality or incurring high costs. To address these challenges, we introduce VALOR (Value-Aligned LLM-Overseen Rewriter), a modular, zero-shot agentic framework for safer and more helpful text-to-image generation. VALOR integrates layered prompt analysis with human-aligned value reasoning: a multi-level NSFW detector filters lexical and semantic risks; a cultural value alignment module identifies violations of social norms, legality, and representational ethics; and an intention disambiguator detects subtle or indirect unsafe implications. When unsafe content is detected, prompts are selectively rewritten by a large language model under dynamic, role-specific instructions designed to preserve user intent while enforcing alignment. If the generated image still fails a safety check, VALOR optionally performs a stylistic regeneration to steer the output toward a safer visual domain without altering core semantics. Experiments across adversarial, ambiguous, and value-sensitive prompts show that VALOR significantly reduces unsafe outputs by up to 100.00% while preserving prompt usefulness and creativity. These results highlight VALOR as a scalable and effective approach for deploying safe, aligned, and helpful image generation systems in open-world settings.
Xiaojun Chen 0004, Bingshan Liu, Zeyao Liu, Zhendong Zhao, Xiaoyan Gu 0001
AAAI5
2026 Buster: Implanting Semantic Backdoor Into Text Encoder to Mitigate NSFW Content Generation
Xiaojun Chen 0004, Yuexin Xuan, Zhendong Zhao, Xinfeng Li, Xiaojun Jia, Xiaofeng Wang 0001
DASFAA (5)4
2026 ComMark: Covert and Robust Black-Box Model Watermarking with Compressed Samples
abstract
The rapid advancement of deep learning has turned models into highly valuable assets due to their reliance on massive data and costly training processes. However, these models are increasingly vulnerable to leakage and theft, highlighting the critical need for robust intellectual property protection. Model watermarking has emerged as an effective solution, with black-box watermarking gaining significant attention for its practicality and flexibility. Nonetheless, existing black-box methods often fail to better balance covertness (hiding the watermark to prevent detection and forgery) and robustness (ensuring the watermark resists removal)—two essential properties for real-world copyright verification. In this paper, we propose ComMark, a novel black-box model watermarking framework that leverages frequency-domain transformations to generate compressed, covert, and attack-resistant watermark samples by filtering out high-frequency information. To further enhance watermark robustness, our method incorporates simulated attack scenarios and a similarity loss during training. Comprehensive evaluations across diverse datasets and architectures demonstrate that ComMark achieves state-of-the-art performance in both covertness and robustness.
Yunfei Yang 0001, Xiaojun Chen 0004, Zhendong Zhao, Yu Zhou 0015, Xiaoyan Gu 0001, Juan Cao 0001
ICMR3
2026 Personalized Subgraph Federated Learning With Decoupled Data Heterogeneity in Mobile-Edge Computing
abstract
Graph Federated Learning (FL) has attracted extensive attention in recent years due to its ability to train global graph models in a distributed manner without exposing original local data. However, fine-grained data heterogeneity remains largely overlooked in collaborative graph model training. Existing graph FL methods that address heterogeneity are mostly adapted from traditional FL and fail to account for the unique complexity of graph-specific heterogeneity. Specifically, graph heterogeneity can be further decomposed into feature heterogeneity and structural heterogeneity, which are tightly coupled during local training. To address this issue, we propose a novel local graph module, Feature and Structure Decoupling Convolution (FSD-Conv), designed to disentangle the interplay between feature bias and structural bias. With FSD-Conv, clients can learn feature-related yet structure-unbiased representations, thereby alleviating the adverse impact of graph heterogeneity in federated training. Furthermore, we introduce FedFSD, a personalized graph FL framework that achieves effective personalized model aggregation through an explainable neural network operating in a low-dimensional space. Extensive experiments on six graph datasets under both disjoint and overlapping client partitioning schemes demonstrate the effectiveness of FedFSD in handling complex graph data heterogeneity.
Bisheng Tang, Xiaojun Chen 0004, Shaopu Wang, Yuexin Xuan, Zhendong Zhao, Xingyu Gao 0001
IEEE Trans. Mob. Comput.5
2025 IPBA: Imperceptible Perturbation Backdoor Attack in Federated Self-Supervised Learning
abstract
Federated Self-Supervised Learning (FSSL) combines the advantages of decentralized modeling and unlabeled representation learning, serving as a cutting-edge paradigm with strong potential for scalability and privacy preservation. Although FSSL has garnered increasing attention, research indicates that it remains vulnerable to backdoor attacks. Existing methods generally rely on visually obvious triggers, which makes it difficult to meet the requirements for stealth and practicality in real-world deployment. In this paper, we propose an imperceptible and effective backdoor attack method against FSSL, called IPBA. Our empirical study reveals that existing imperceptible triggers face a series of challenges in FSSL, particularly limited transferability, feature entanglement with augmented samples, and out-of-distribution properties. These issues collectively undermine the effectiveness and stealthiness of traditional backdoor attacks in FSSL. To overcome these challenges, IPBA decouples the feature distributions of backdoor and augmented samples, and introduces Sliced-Wasserstein distance to mitigate the out-of-distribution properties of backdoor samples, thereby optimizing the trigger generation process. Our experimental results on several FSSL scenarios and datasets show that IPBA significantly outperforms existing backdoor attack methods in performance and exhibits strong robustness under various defense mechanisms.
Jiayao Wang 0004, Zhendong Zhao, Junwu Zhu, Dongfang Zhao 0001
ECAI3
2025 Take Attention Inside: Neighbor Pair Graph Contrastive Learning
abstract
Graph Contrastive Learning(GCL) is a fundamental pretraining research method in Graph Neural Networks (GNNs), which puts rich graph-level insights into the graph data to augment the data representation. However, since the existing GCLs generally regard the intra-layer node as negative samples, they cannot cope with the diverse coupled neighbor relationships, which can be pre-trained with the combination of negative and positive samples. Coupled relationships can keep the attribute preference in node-level contrast and correctly pass this preference into the downstream tasks. To further prove the effectiveness of coupled neighbor relationships in the pretraining phase, we propose a novel GNN pretraining model Neighbor Pair Contrastive Graph Siamese Networks (NPC-GSN) for graph contrast. NPC-GSN expands the dissimilar neighbor’s representation discrepancy and decreases the representation discrepancy of similar neighbors in the pretraining phase, aiming to promote downstream node classification. Our extensive experiments on five graph datasets against several pretraining GNN models demonstrate the competitive effectiveness of NPC-GSN in node classification, and the frequency domain and ablation experiments also verify the effectiveness of NPC-GSN.
Bisheng Tang, Xiaojun Chen 0004, Shaopu Wang, Yuexin Xuan, Zhendong Zhao
ICASSP5
2025 Model-Guardian: Protecting against Data-Free Model Stealing Using Gradient Representations and Deceptive Predictions
abstract
Model stealing attack is increasingly threatening the confidentiality of machine learning models deployed in the cloud. Recent studies reveal that adversaries can exploit data synthesis techniques to steal machine learning models even in scenarios devoid of real data, leading to data-free model stealing attacks. Existing defenses against such attacks suffer from limitations, including poor effectiveness, insufficient generalization ability, and low comprehensiveness. In response, this paper introduces a novel defense framework named Model-Guardian. Comprising two components, Data-Free Model Stealing Detector (DFMS-Detector) and Deceptive Predictions (DPreds), Model-Guardian is designed to address the shortcomings of current defenses with the help of the artifact properties of synthetic samples and gradient representations of samples. Extensive experiments on seven prevalent data-free model stealing attacks showcase the effectiveness and superior generalization ability of Model-Guardian, outperforming eleven defense methods and establishing a new state-of-the-art performance. Notably, this work pioneers the utilization of various GANs and diffusion models for generating highly realistic query samples in attacks, with Model-Guardian demonstrating accurate detection capabilities.
Yunfei Yang 0001, Xiaojun Chen 0004, Yuexin Xuan, Zhendong Zhao
ICME4
2025 Who Speaks for the Trigger? Dynamic Expert Routing in Backdoored Mixture-of-Experts Transformers
abstract
Large language models (LLMs) with Mixture-of-Experts (MoE) architectures achieve impressive performance and efficiency by dynamically routing inputs to specialized subnetworks, known as experts. However, this sparse routing mechanism inherently exhibits task preferences due to expert specialization, introducing a new and underexplored vulnerability to backdoor attacks. In this work, we investigate the feasibility and effectiveness of injecting backdoors into MoE-based LLMs by exploiting their inherent expert routing preferences. We thus propose \textbf{BadSwitch}, a novel backdoor framework that integrates task-coupled dynamic trigger optimization with a sensitivity-guided Top-S expert tracing mechanism. Our approach jointly optimizes trigger embeddings during pretraining while identifying S most sensitive experts, subsequently constraining the Top-K gating mechanism to these targeted experts. Unlike traditional backdoor attacks that rely on superficial data poisoning or model editing, BadSwitch primarily embeds malicious triggers into expert routing paths with strong task affinity, enabling precise and stealthy model manipulation. Through comprehensive evaluations across three prominent MoE architectures (Switch Transformer, QwenMoE, and DeepSeekMoE), we demonstrate that BadSwitch can efficiently hijack pre-trained models with up to 100\% success rate (ASR) while maintaining the highest clean accuracy (ACC) among all baselines. Furthermore, BadSwitch exhibits strong resilience against both text-level and model-level defense mechanisms, achieving 94.07\% ASR and 87.18\% ACC on the AGNews dataset. Our analysis of expert activation patterns reveals fundamental insights into MoE vulnerabilities. We anticipate this work will expose security risks in MoE systems and contribute to advancing AI safety.
Bingshan Liu, Zhendong Zhao
NeurIPS5
2025 ColorFP: Improving AI-Generated Text Detection via Fixed Vocabulary Partitioning and Half-Bit Fingerprinting
He Li 0010, Xiaojun Chen 0004, Yunfei Yang 0001, Zhendong Zhao, Shuguang Yuan 0003
PRICAI (4)4
2025 FedShelter: Efficient privacy-preserving federated learning with poisoning resistance for resource-constrained IoT network
Tingyu Fan, Xiaojun Chen 0004, Ye Dong, Weizhan Jing, Zhendong Zhao
Comput. Networks6
2024 CipherDM: Secure Three-Party Inference for Diffusion Model Sampling
Xiaojun Chen 0004, He Li 0010, Tingyu Fan, Zhendong Zhao
ECCV (71)6
2024 DualCOS: Query-Efficient Data-Free Model Stealing with Dual Clone Networks and Optimal Samples
abstract
Although data-free model stealing attacks are free from reliance on real data, they suffer from limitations, including low accuracy and high query budgets, which restrict their practical feasibility. In this paper, we propose a novel data-free model stealing framework called DualCOS. As a whole, DualCOS is divided into two stages: interactive training and semi-supervised boosting. To optimize the usage of query budgets, we use a dual clone model architecture to address the challenge of querying victim model during generator training. We also introduce active learning-based sampling strategy and sample reuse mechanism to achieve an efficient query process. Furthermore, once query budget is exhausted, the semi-supervised boosting is employed to continue improving the final clone accuracy. Through extensive evaluations, we demonstrate the superiority of our proposed method in terms of accuracy and query efficiency, particularly in scenarios involving hard labels and multiple classes.
Yunfei Yang 0001, Xiaojun Chen 0004, Yuexin Xuan, Zhendong Zhao
ICME4
2024 Progtuning: Progressive Fine-Tuning Framework for Transformer-Based Language Models
Xiaoshuang Ji, Zhendong Zhao, Xiaojun Chen 0004, Zeyao Liu
ICONIP (9)2
2024 STMS: An Out-Of-Distribution Model Stealing Method Based on Causality
abstract
Machine learning, particularly deep learning, is extensively applied in various real-life scenarios. However, recent research has highlighted the severe infringement of privacy and intellectual property caused by model stealing attacks. Therefore, more researchers are dedicated to studying the principles and methods of such attacks to promote the security development of artificial intelligence. Most of the existing model stealing attacks rely on prior information of the attacked models and consider ideal conditions. In order to better understand and defend against model stealing in real-world scenarios, we propose a novel model stealing method, named STMS, based on causal inference learning. For the first time, we introduce the problem of out-of-distribution generalization into the model stealing domain. The proposed approach operates under more challenging conditions, where the training and testing data of the target model are unknown, black-box, hard-label outputs, and there is a distribution shift during the testing phase. STMS achieves comparable or better stealing accuracy and generalization performance than prior works on multiple datasets and tasks. Moreover, this universal framework can be applied to improve the effectiveness of other model stealing methods and can also be migrated to other areas of machine learning.
Yunfei Yang 0001, Xiaojun Chen 0004, Zhendong Zhao, Yuexin Xuan, Bisheng Tang
IJCNN3
2023 KRec-C2: A Knowledge Graph Enhanced Recommendation with Context Awareness and Contrastive Learning
Yingtao Peng, Zhendong Zhao, Aishan Maoliniyazi, Xiaofeng Meng 0001
DASFAA (2)2
2023 Unsupervised Graph Structure-Assisted Personalized Federated Learning
abstract
Non-IID data presents a significant challenge for federated learning(FL), and personalized FL is a natural solution to address this challenge. Recently, Graph Neural Network (GNN) has recently emerged to model the complex client relationship using a client graph to refine personalized models. However, this approach depends on an existing client relation graph on the server, making it impractical unless this prerequisite is satisfied. Furthermore, noisy and missing connections in the original graph structures can degrade personalization performance. In this work, we propose an unsupervised structure learning approach to improve personalized FL, where the server learns a dynamic client graph through self-supervision and generates structure-based client representations. These representations are then broadcasted to users, regulating local training using the learned knowledge as an inductive bias. Empirical studies on benchmark datasets demonstrate the significant effectiveness of our approach and the high quality of the client graphs. The code is available at https://github.com/lazyJane/FedSKA.
Xiaojun Chen 0004, Bisheng Tang, Shaopu Wang, Yuexin Xuan, Zhendong Zhao
ECAI6
2023 Practical and General Backdoor Attacks Against Vertical Federated Learning
Yuexin Xuan, Xiaojun Chen 0004, Zhendong Zhao, Bisheng Tang, Ye Dong
ECML/PKDD (2)3
2023 Generalized heterophily graph data augmentation for node classification
Bisheng Tang, Xiaojun Chen 0004, Shaopu Wang, Yuexin Xuan, Zhendong Zhao
Neural Networks5
2022 DEFEAT: Deep Hidden Feature Backdoor Attacks by Imperceptible Perturbation and Latent Representation Constraints
abstract
Backdoor attack is a type of serious security threat to deep learning models. An adversary can provide users with a model trained on poisoned data to manipulate prediction behavior in test stage using a backdoor. The backdoored models behave normally on clean images, yet can be activated and output incorrect prediction if the input is stamped with a specific trigger pattern. Most existing backdoor attacks focus on manually defining imperceptible triggers in input space without considering the abnormality of triggers' latent representations in the poisoned model. These attacks are susceptible to backdoor detection algorithms and even visual inspection. In this paper, We propose a novel and stealthy backdoor attack - DEFEAT. It poisons the clean data using adaptive imperceptible perturbation and restricts latent representation during training process to strengthen our attack's stealthiness and resistance to defense algorithms. We conduct extensive experiments on multiple image classifiers using real-world datasets to demonstrate that our attack can 1) hold against the state-of-the-art defenses, 2) deceive the victim model with high attack success without jeopardizing model utility, and 3) provide practical stealthiness on image data.
Zhendong Zhao, Xiaojun Chen 0004, Yuexin Xuan, Ye Dong, Dakui Wang, Kaitai Liang
CVPR1
2022 KAFNN: A Knowledge Augmentation Framework to Graph Neural Networks
abstract
The semi-supervised node classification task is a basic problem in graph neural networks(GNNs). GNNs have shown their superiority in graph datasets over traditional neural networks such as Multilayer Perceptron. However, due to the limitation of Weisfeiler-Lehman, the existing GNNs will discard some prior knowledge, which is hard to be coped with, such as Dropout skill, etc. In this paper, we proposed a framework called KAFNN to introduce knowledge discarded obliviously to enhance data representation. KAFNN, based on the Siamese network, introduces the framework of combining GNNs and deep neural networks(DNNs) to capture the data presentation as whole as possible, which will inject more knowledge into GNNs. Extensive experiments based on seven public datasets and seven GNN models have shown that KAFNN has promoted presentation of several state-of-the-art GNN models in a competitive performance.
Bisheng Tang, Xiaojun Chen 0004, Dakui Wang, Zhendong Zhao
IJCNN4
2022 Rethinking the Feature Iteration Process of Graph Convolution Networks
abstract
Node classification is a fundamental research problem in graph neural networks(GNNs), which uses node's feature and label to capture node embedding in a low dimension. The existing graph node classification approaches mainly focus on GNNs from global and local perspectives. The relevant research is relatively insufficient for the micro perspective, which refers to the feature itself. In this paper, we prove that deeper GCNs' features will be updated with the same coefficient in the same dimension, limiting deeper GCNs' expression. To overcome the limits of the deeper GCN model, we propose a zero feature (k-ZF) method to train GCNs. Specifically, k-ZF randomly sets the initial k feature value to zero, acting as a data rectifier and augmenter, and is also a skill equipped with GCNs models and other GCNs skills. Extensive experiments based on three public datasets show that k-ZF significantly improves GCNs in the feature aspect and achieves competitive accuracy.
Bisheng Tang, Xiaojun Chen 0004, Dakui Wang, Zhendong Zhao
IJCNN4
2022 ACTSS: Input Detection Defense against Backdoor Attacks via Activation Subset Scanning
abstract
Deep neural networks are vulnerable to backdoor attacks where adversaries inject the trigger into partial training data to manipulate the trained model misclassification. In addition, the poisoned model behaves normally on clean inputs, and the malicious behavior only occurs when the secret trigger is present, making backdoor attacks hard to be detected. Most existing input detection methods leverage the link between triggers and outputs to reveal the poisoned inputs, which suffer from the trigger-size or the “all-to-all” attack scenario. We show that the internal activations produced by benign and poisoned inputs are significantly different in the poisoned model. In this paper, we propose a novel and run-time input detection algorithm, Activation Subset Scanning (ACTSS), which extracts the activations of incoming inputs and leverages an anomaly detection algorithm to identify malicious inputs. We search and score for the abnormal activation subset according to the statistical difference of activations between benign and poisoned data using nonparametric statistics technology. Extensive experiments are conducted on three public datasets: CIFAR10, GTSRB, and ImageNet, with three representative models. The results verify our approach's effectiveness and state-of-the-art performance, which achieve over 98% false rejection rate for different types of triggers.
Yuexin Xuan, Xiaojun Chen 0004, Zhendong Zhao, Yangyang Ding, Jianming Lv
IJCNN3
2021 A Novel Privacy-Preserving Neural Network Computing Approach for E-Health Information System
abstract
Electronic health (e-health) information system relies on cloud computing technologies to provide massive medical data computing and storage services. Especially, the recently proposed Machine Learning as a Service (MLaaS) on these medical data can not only effectively improve the healthcare service quality, but also support the end users with limited computing resources. However, MLaaS on the massive medical data faces the challenge of privacy. Homomorphic encryption technology has been explored to assure the privacy of medical data owners in MLaaS but with the weaknesses of limited homomorphic operations and low efficiency. To alleviate these weaknesses, this paper proposes a novel privacy-preserving non-collusion dualcloud (NCDC) model-based e-health information system using neural network (NN) computing. The system can not only assure medical data privacy through adopting homomorphic encryption technology but also assure NN model privacy by adding fake neurons to the NN. In addition, the proposed e-health information system also has the following advantages: (i) Simple key generation. (ii) No constraint on the size of medical data to be encrypted. (iii) The less loss of prediction accuracy between encrypted and original medical data. (iv) Supporting more homomorphic operations and having better computing efficiency through experiment verification.
Yingying Yao, Zhendong Zhao, Xiaolin Chang, Jelena V. Misic, Vojislav B. Misic, Jianhua Wang 0004
ICC2
2021 Robust node embedding against graph structural perturbations
Zhendong Zhao, Xiaojun Chen 0004, Dakui Wang, Yuexin Xuan
Inf. Sci.1
2015 A Computationally Efficient Algorithm for Learning Topical Collocation Models
abstract
Zhendong Zhao, Lan Du, Benjamin Börschinger, John K Pate, Massimiliano Ciaramita, Mark Steedman, Mark Johnson. Proceedings of the 53rd Annual Meeting of the Association for Computational Linguistics and the 7th International Joint Conference on Natural Language Processing (Volume 1: Long Papers). 2015.
Zhendong Zhao, Lan Du 0002, Benjamin Börschinger, John K. Pate, Massimiliano Ciaramita, Mark Steedman, Mark Johnson 0001
ACL (1)1
2015 A generative Bayesian model to identify cancer driver genes
abstract
Cancer is a disease characterized largely by the accumulation of somatic mutations during the lifetime of a patient. Distinguishing driver mutations from passenger mutations had posed a challenge in modern cancer research. With the state of art of microarray technologies and clinical studies, a large numbers of candidate genes are extracted. Extracting informative genes out of them is essential. In our project we aim to find the cancer driver genes using somatic mutation data and protein protein interaction data. We developed a generative mixture model coupled with Bayesian parameter estimation to estimate background mutation rates and driver probabilities of each gene as well as the proportion of drivers among all sequenced genes. We choose suitable prior distributions for modelling both driver probabilities and background mutations of each gene. We apply our method to ovarian cancer data and numerically estimated the solution. Upon convergence, we are able to discover and identify some new candidate cancer driver genes.
Christopher Ma, Zhendong Zhao, Tina Gui, Yixin Chen 0002, Xin Dang, Dawn Wilkins
BIBM2
2013 Drug activity prediction using multiple-instance learning via joint instance and feature selection
abstract
BACKGROUND: In drug discovery and development, it is crucial to determine which conformers (instances) of a given molecule are responsible for its observed biological activity and at the same time to recognize the most representative subset of features (molecular descriptors). Due to experimental difficulty in obtaining the bioactive conformers, computational approaches such as machine learning techniques are much needed. Multiple Instance Learning (MIL) is a machine learning method capable of tackling this type of problem. In the MIL framework, each instance is represented as a feature vector, which usually resides in a high-dimensional feature space. The high dimensionality may provide significant information for learning tasks, but at the same time it may also include a large number of irrelevant or redundant features that might negatively affect learning performance. Reducing the dimensionality of data will hence facilitate the classification task and improve the interpretability of the model. RESULTS: In this work we propose a novel approach, named multiple instance learning via joint instance and feature selection. The iterative joint instance and feature selection is achieved using an instance-based feature mapping and 1-norm regularized optimization. The proposed approach was tested on four biological activity datasets. CONCLUSIONS: The empirical results demonstrate that the selected instances (prototype conformers) and features (pharmacophore fingerprints) have competitive discriminative power and the convergence of the selection process is also fast.
Zhendong Zhao, Khaled M. Elokely, Robert J. Doerksen, Yixin Chen 0002, Dawn Wilkins
BMC Bioinform.1
2012 A Split-Merge Framework for Comparing Clusterings
Qiaoliang Xiang, Qi Mao 0001, Kian Ming A. Chai, Hai Leong Chieu, Ivor W. Tsang, Zhendong Zhao
ICML6
2011 Sensor-Assisted Video Encoding for Mobile Devices in Real-World Environments
abstract
In this paper, we present a comprehensive study on sensor-assisted video encoding (SaVE) schemes for video capturing on mobile devices in real-world environments. Our purpose is to reduce the computational complexity of video encoding by leveraging sensors that are increasingly available on mobile devices, e.g., accelerometers and digital compasses. Motion estimation is a key component of video encoding. In this paper, SaVE calculates the rotational movement of a camera (on mobile devices) and then infers the global motion in the camera imager. SaVE subsequently employs the estimated global motion as predictors to simplify motion estimation algorithms for state-of-the-art H.264/AVC video coding. We have constructed a prototype of SaVE and evaluated its performance with a pair of accelerometers, a digital compass, and their combination. Our experimental results show that SaVE can significantly reduce the computations of motion estimation while achieving equal or better video quality. Our results also show that SaVE has a strong noise-resistant capability. Therefore, it can be practically employed in real-world environments.
Xiaoming Chen 0006, Zhendong Zhao, Ahmad Rahmati, Ye Wang 0007, Lin Zhong 0001
IEEE Trans. Circuits Syst. Video Technol.2
2010 Large-scale music tag recommendation with explicit multiple attributes
abstract
Social tagging can provide rich semantic information for large-scale retrieval in music discovery. Such collaborative intelligence, however, also generates a high degree of tags unhelpful to discovery, some of which obfuscate critical information. Towards addressing these shortcomings, tag recommendation for more robust music discovery is an emerging topic of significance for researchers. However, current methods do not consider diversity of music attributes, often using simple heuristics such as tag frequency for filtering out irrelevant tags. Music attributes encompass any number of perceived dimensions, for instance vocalness, genre, and instrumentation. Many of these are underrepresented by current tag recommenders. We propose a scheme for tag recommendation using Explicit Multiple Attributes based on tag semantic similarity and music content. In our approach, the attribute space is explicitly constrained at the outset to a set that minimizes semantic loss and tag noise, while ensuring attribute diversity. Once the user uploads or browses a song, the system recommends a list of relevant tags in each attribute independently. To the best of our knowledge, this is the first method to consider Explicit Multiple Attributes for tag recommendation. Our system is designed for large-scale deployment, on the order of millions of objects. For processing large-scale music data sets, we design parallel algorithms based on the MapReduce framework to perform large-scale music content and social tag analysis, train a model, and compute tag similarity. We evaluate our tag recommendation system on CAL-500 and a large-scale data set ($N = 77,448$ songs) generated by crawling Youtube and Last.fm. Our results indicate that our proposed method is both effective for recommending attribute-diverse relevant tags and efficient at scalable processing.
Zhendong Zhao, Xinxi Wang, Qiaoliang Xiang, Andy M. Sarroff, Ye Wang 0007
ACM Multimedia1
2009 SaVE: sensor-assisted motion estimation for efficient h.264/AVC video encoding
abstract
Motion estimation is a key component of modern video encoding and is very compute-intensive. We present a novel Sensor-assisted Video Encoding (SaVE) method to reduce the computational complexity of motion estimation in H.264/AVC encoders, leveraging accelerometers and digital compasses that are increasingly available on mobile devices. Using these sensors, SaVE calculates the rotational movement of a camera and then infers the global motion in the camera image sensor; it subsequently employs the estimated global motion to simplify the state-of-the-art motion estimation algorithms, UMHS and EPZS used in H.264/AVC encoders. We have constructed a prototype of SaVE and report extensive evaluation of it. Our experimental results show that SaVE can reduce the computations of UMHS and EPZS algorithms by up to 27% and 18%, respectively, while achieving the same or better video quality.
Xiaoming Chen 0006, Zhendong Zhao, Ahmad Rahmati, Ye Wang 0007, Lin Zhong 0001
ACM Multimedia2
2007 A Novel Model of Working Set Selection for SMO Decomposition Methods
abstract
In the process of training support vector machines (SVMs) by decomposition methods, working set selection is an important technique, and some exciting schemes were employed into this field. To improve working set selection, we propose a new model for working set selection in sequential minimal optimization (SMO) decomposition methods. In this model, it selects B as working set without reselection. Some properties are given by simple proof, and experiments demonstrate that the proposed method is in general faster than existing methods.
Zhendong Zhao, Forrest Sheng Bao, Shun-Yi Zhang, Yan-Fei Sun
ICTAI (2)1