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Ching-Ti Liu

dblp:47/6230 · DBLP profile ↗
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1ranked-venue papers
0as first author
1since 2021 · last 2023
0000-0002-0703-0742ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Medical and health informatics · 67% Bioinformatics and computational biology · 33%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Medical and health informatics › precision medicine
disease subtype discovery
0.712023
Information-incorporated sparse convex clustering for disease subtyping · Bioinform. 2023
Medical and health informatics › clinical data analysis › phenotyping
disease subtyping
0.712023
Information-incorporated sparse convex clustering for disease subtyping · Bioinform. 2023
Bioinformatics and computational biology
multi-omics data integration
0.712023
Information-incorporated sparse convex clustering for disease subtyping · Bioinform. 2023

Methods — techniques the papers use, named apart from their topics

text mining · 0.7sparse convex clustering · 0.7group lasso · 0.7
YearPublicationVenuePosition
2023 Information-incorporated sparse convex clustering for disease subtyping
abstract
MOTIVATION: Heterogeneity in human diseases presents clinical challenges in accurate disease characterization and treatment. Recently available high throughput multi-omics data may offer a great opportunity to explore the underlying mechanisms of diseases and improve disease heterogeneity assessment throughout the treatment course. In addition, increasingly accumulated data from existing literature may be informative about disease subtyping. However, the existing clustering procedures, such as Sparse Convex Clustering (SCC), cannot directly utilize the prior information even though SCC produces stable clusters. RESULTS: We develop a clustering procedure, information-incorporated Sparse Convex Clustering, to respond to the need for disease subtyping in precision medicine. Utilizing the text mining approach, the proposed method leverages the existing information from previously published studies through a group lasso penalty to improve disease subtyping and biomarker identification. The proposed method allows taking heterogeneous information, such as multi-omics data. We conduct simulation studies under several scenarios with various accuracy of the prior information to evaluate the performance of our method. The proposed method outperforms other clustering methods, such as SCC, K-means, Sparse K-means, iCluster+, and Bayesian Consensus Clustering. In addition, the proposed method generates more accurate disease subtypes and identifies important biomarkers for future studies in real data analysis of breast and lung cancer-related omics data. In conclusion, we present an information-incorporated clustering procedure that allows coherent pattern discovery and feature selection. AVAILABILITY AND IMPLEMENTATION: The code is available upon request.
Ching-Ti Liu
Bioinform.2