Proteins interact with other proteins and bio-molecules to form a complex and execute key biological functions in a living organism, and respond to several environmental signals. Designing efficient predictive models for protein complexes is a challenging task with limited coverage in the contemporary literature. With this motivation, we have developed a novel method, PCPredG, for 3-node protein complex prediction from PPI networks using 5-node graphlet features. CORUM protein complex repository has been used to curate positive and negative data samples with the help of MCODE and MCL clustering algorithms. During experiments, Random Forest(RF) and SVM classifiers are trained with 1000 positive 3-node complexes in 10-fold cross-validation setup and with 1:1 to 1:10 positive-negative proportions. In parallel, we have implemented the state-of-the-art GCN with polarised message-passing, GAT and an ensemble of GCN and GAT in both balanced and imbalanced setups. We also introduced a 10-fold quality consensus on the hold-out set across all the experiments. We have achieved the best performances with the RF classifier in both balanced and imbalanced experiments.

Handwritten script classification is still considered as a challenging research problem in the domain of document image analysis. Although some research attempts have been made by the researchers for solving the challenging issues, a comprehensive solution is yet to be achieved. The case study, undertaken here, analyzes the performances of various state-of-the art handwritten script classification methods for Indian scripts where features, needed for the script classification task, are extracted from the script images at four different granularity levels, i.e., page, block, text line, or word. The results of handwritten script classification at each level have been obtained and compared using eight different feature sets and six different state-of-the-art classifiers. Based on the classification results, an ideal level for performing the handwritten script classification task is suggested among these four classification levels. The results have also been improved by using two feature dimensionality reduction methods. All these experiments are done on two different handwritten Indic script databases, of which one is an in-house developed dataset and the other one is a freely available dataset. Finally, some future research directions that may be undertaken by the researchers as an application of the handwritten Indic script classification problem are also highlighted. The work presented here provides a basic foundation for the construction of a comprehensive handwritten script classification method for official Indian scripts.

Over the years, several methods have been proposed for the computational PPI prediction with different performance evaluation strategies. While attempting to benchmark performance scores, most of these methods often suffer with ill-treated cross-validation strategies, adhoc selection of positive/negative samples etc. To address these issues, in our proposed multi-level feature based PPI prediction approach (JUPPI), using sequence, domain and GO information as features, a refined evaluation strategy has been introduced. During the evaluation process, we first extract high quality negative data using three-stage filtering, and then introduce a pair-input based cross validation strategy with three difficulty levels for test-set predictions. Our proposed evaluation strategy reduces the component-level overlapping issue in test sets. Performance of JUPPI is compared with those of the state-of-the-art approaches in this domain and tested on six independent PPI datasets. In almost all the datasets, JUPPI outperforms the state-of-the-art not only at human proteome level for PPI prediction, but also for prediction of interactors for intrinsic disordered human proteins. https://figshare.com/projects/JUPPI_A_Multi-level_Feature_Based_Method_for_PPI_Prediction_and_a_Refined_Strategy_for_Performance_Assessment/81656 JUPPI tool and the developed datasets (JUPPId) are available in public domain for academic use along with supplementary materials, which can be found on the Computer Society Digital Library at http://doi.ieeecomputersociety.org/10.1109/TCBB.2020.3004970.

Abstract Handwritten numeral recognition is a challenging research problem because of the enormous varieties of styles in which human beings write the numerals. Several researchers have tried to find solutions to this problem with exceptional recognition accuracies. However, most of these solutions have been dedicated to single script numerals. Such methods are inappropriate for multi‐lingual nations such as India where a large number of scripts are used. Keeping this issue in mind, a new feature descriptor named symbolization of binary images (SBI) is introduced here for the recognition of handwritten numerals of different scripts. Effectiveness of SBI is supported with experiments showing its script‐invariant nature. Classification of numerals using a multiclass support vector machine (SVM) classifier yields the recognition accuracies of 98.18, 96.22, 96.52, and 95.53% on datasets of numerals written in four popular scripts of the world: Arabic, Bangla, Devanagari, and Latin, respectively. This scheme has also been extended to the situation when the script used is not known a priori or the numerals written in a document belong to pairs of mixed scripts of {Arabic, Devanagari, Bangla} with Latin producing recognition rates of 92.97, 91.25, and 91.67%, respectively. When all four scripts are mixed, the recognition rate is still 90.98% overall. Encouraging outcomes suggest that the proposed SBI feature descriptor can recognize numerals invariant of the script class.

This paper proposes a novel local feature descriptor coined as a local instant-and-center-symmetric neighbor-based pattern of the extrema-images (LINPE) to detect breast abnormalities in thermal breast images. It is a hybrid descriptor that combines two different feature descriptors: one is the inverse-probability difference extrema (IpDE), and another is the local instant and center-symmetric neighbor-based pattern (LICsNP). IpDE is developed to compute the intensity-inhomogeneity-invariant feature-based image of the breast thermogram. Besides, the LICsNP is intended to capture the local microstructure pattern information in the IpDE image. A new paradigm, named Broad Learning (BL) network, is introduced here as a classifier to differentiate the healthy and sick breast thermograms efficiently. The efficacy of the proposed system is quantitatively validated on the images of DMR-IR and DBT-TU-JU databases. Extensive experimentation on these databases with an average accuracy of 96.90% and 94%, respectively, justifies proposed system's superiority in the differentiation of healthy and sick breast thermograms over the other related existing state-of-the-art methods. The proposed system also performs consistently in the presence of noise and rotational changes.

Identifying skin diseases, such as leprosy, Tinea Versicolor, and Vitiligo identification is one of the challenging tasks. Therefore, skin disease identification success rate is comparatively poor as compared to the other computer vision tasks. Traditional Deep Learning (DL) models are not successful in this domain due to the lack of a huge number of data. To address the problem, in the present work, we introduced a customized Generative Adversarial Network (GAN) to generate synthetic data. With data augmentation, we achieved maximum 94.25% recognition accuracy using DensenNet-121, which was 10.95% better than when no augmentation was employed. Source code is publicly available at https://github.com/DVLP-CMATERJU/SkinDiseases_GenerativeAI.git GitHub.

Capturing images of documents is one of the easiest and most used methods of recording them. These images however, being captured with the help of handheld devices, often lead to undesirable distortions that are hard to remove. We propose a supervised Gated and Bifurcated Stacked U-Net module to predict a dewarping grid and create a distortion free image from the input. While the network is trained on synthetically warped document images, results are calculated on the basis of real world images. The novelty in our methods exists not only in a bifurcation of the U-Net to help eliminate the intermingling of the grid coordinates, but also in the use of a gated network which adds boundary and other minute line level details to the model. The end-to-end pipeline proposed by us achieves state-of-the-art performance on the DocUnet dataset after being trained on just 8 percent of the data used in previous methods.

The writing style is a unique characteristic of a human being as it varies from one person to another. Due to such diversity in writing style, handwritten character recognition (HCR) under the purview of pattern recognition is not trivial. Conventional methods used handcrafted features that required a-priori domain knowledge, which is always not feasible. In such a case, extracting features automatically could potentially attract more interests. For this, in the literature, convolutional neural network (CNN) has been a popular approach to extract features from the image data. However, state-of-the-art works do not provide a generic CNN model for character recognition, Devanagari script, for instance. Therefore, in this work, we first study several different CNN models on publicly available handwritten Devanagari characters and numerals datasets. This means that our study is primarily focusing on comparative study by taking trainable parameters, training time and memory consumption into account. Later, we propose and design DevNet, a modified CNN architecture that produced promising results, since computational complexity and memory space are our primary concerns in design.

Abstract In India, which has numerous officially recognized scripts, there is a primary need for categorizing the documents on the basis of the scripts used therein. Identification of script used in a document is essential for its effective handling both manually and digitally. Identification of script in a document image is an important research problem in the pattern recognition field, which, at times, suffers from the issue of growing dimensionality of the feature vector and requires an efficient feature selection technique. Keeping this fact in mind, in this paper, we propose a clustering‐based filter feature selection framework in order to extract an optimal and effective feature subset from the original feature vector. The present feature selection methodology is evaluated on a script classification problem involving handwritten documents in 12 major Indic scripts. Experiments are done at word‐level, text‐line‐level, and block‐level. Experiments demonstrate that a reasonable increment in classification accuracy has been realized using comparatively lesser number of features. The proposed framework for feature selection is computationally inexpensive and can be applied to other pattern recognition problems as well.

We present a human protein cluster analysis by combining: 1) n-gram based amino acid frequency features, 2) optimal feature selection, 3) hierarchical clustering, and 4) advanced partitioning techniques. Our method qualitatively and quantitatively groups proteins with increasing sequence similarity into similar clusters by calculating the frequency model of amino acids using n-grams. We experiment with n = 1, i.e., unigrams, n = 2, i.e., bigrams, and finally n = 3, i.e., trigrams for optimal selection of features to design the 3gClust algorithm. The benchmarking results on 20,105 manually curated human proteins show that 3gClust ensures better cluster compactness in the case of proteins with similar functional groups, biological processes, structural alignment, and shared domains (e.g., aquaporins, keratins). Quantitative analysis of non singleton clusters shows significant improvement in their compactness in comparison to other state-of-the art methodologies. 3gClust is available at https://sites.google.com/site/bioinfoju/projects/3gclust for academic use along with supplementary materials, which can be found on the Computer Society Digital Library at http://doi.ieeecomputersociety.org/10.1109/TCBB.2018.2840996, and datasets.

Segmentation of suspicious regions (SRs) of a thermal breast image (TBI) is a very significant and challenging problem for the identification of breast cancer. Therefore, in this work, we have proposed an active contour model for the segmentation of the SRs in TBI. The proposed segmentation method combines three significant steps. First, a novel method, called smaller-peaks corresponding to the high-intensity-pixels and the centroid-knowledge of SRs (SCH-CS), is proposed to approximately locate the SRs, whose contours are later used as the initial evolving curves of the level set method (LSM). Second, a new energy functional, called different local priorities embedded (DLPE), is proposed regarding the level set function. DLPE is then minimized using the interleaved level set evolution to segment the potential SRs in TBI more accurately. Finally, a new stopping criterion is incorporated into the proposed LSM. The proposed LSM not only increases the segmentation speed but also ameliorates the segmentation accuracy. The performance of our SR segmentation method was evaluated on two TBI databases, namely, DMR-IR and DBT-TU-JU, and the average segmentation accuracies obtained on these databases are 72.18% and 71.26% respectively, which are better than the other state-of-the-art methods. Beside this, a novel framework to analyze TBIs is proposed for differentiating abnormal and normal breasts on the basis of the segmented SRs. We have also shown experimentally that investigating only the SRs instead of the whole breast is more effective in differentiating abnormal and normal breasts.

Abstract Classifier combination methods have proved to be an effective tool to increase the performance of classification techniques that can be used in any pattern recognition applications. Despite a significant number of publications describing successful classifier combination implementations, the theoretical basis is still not matured enough and achieved improvements are inconsistent. In this paper, we propose a novel statistical validation technique known as correlation‐based classifier combination technique for combining classifier in any pattern recognition problem. This validation has significant influence on the performance of combinations, and their utilization is necessary for complete theoretical understanding of combination algorithms. The analysis presented is statistical in nature but promises to lead to a class of algorithms for rank‐based decision combination. The potentials of the theoretical and practical issues in implementation are illustrated by applying it on 2 standard datasets in pattern recognition domain,namely, handwritten digit recognition and letter image recognition datasets taken from UCI Machine Learning Database Repository ( http://www.ics.uci.edu/_mlearn ). An empirical evaluation using 8 well‐known distinct classifiers confirms the validity of our approach compared to some other combinations of multiple classifiers algorithms. Finally, we also suggest a methodology for determining the best mix of individual classifiers.

Abstract This paper presents a new hybrid fusion framework based on thermal and visible face images. Fusion of information is done here in two phases, first at the pixel level and then at the decision level. For the pixel level fusion process, à‐trous wavelet transform is applied on both the thermal and visible face images. In decision level fusion, 34 region classifiers, each concentrating on a specified region of the face image, are tested individually for their ability to identify a person from the face image. The region classifiers, which contribute significantly in recognizing the face image, are considered for decision level fusion using majority voting. All experiments have been conducted on the UGC‐JU face database and IRIS benchmark face database. The maximum recognition rate is about 97.22% for both the databases whereas decisions of 17 region classifiers among 34 are considered. Experimental results and comparative study show that the proposed fusion method provides a framework for recognition of face images in uncontrolled environments such as variations in illumination conditions, pose, and facial expressions.

Object localization is one of the inherent tasks of computer vision. It plays an intrinsic role in object detection tasks that initiate with a recognition procedure of figuring out the presence of single/multiple instances of objects of interest in a given image. It involves determination of precise locations of object instances. This paper presents an overview of some of the popularly used approaches to the object localization problem, involving efficient branch-and-bound strategy for sub-window search, super-pixel neighborhood information based approach, boosted local structured Histogram of Oriented Gradients-Local Binary Patterns (HOG-LBP) based strategy, multi-instance learning based weakly supervised object localization, object localization by utilizing deep networks and image tag based object localization. The performance of the mentioned approaches have been compared on the basis of their results on PASCAL-VOC 2007 dataset.

A new image fusion algorithm based on the visible and thermal images for face recognition is presented in this paper. The new fusion algorithm derives the benefit from both the modalities images. The proposed fusion process is the weighted sum of thermal and visible face information with two weighting factors [Formula: see text] and [Formula: see text], respectively. The weighting factors are calculated using a directed search algorithm automatically. The proposed fusion framework is evaluated through extensive experiments using UGC-JU face database. Experiments are of three fold. Firstly, individual modalities images are used separately for human face recognition. Secondly, fused face images using the proposed method are used for recognition purpose. The highest level of accuracy achieved by using the proposed method is about 98.42%. Lastly, the three existing fusion methods are applied on the same face database for comparison with the results of the proposed method. All the results demonstrate significant performance improvements in recognition over individual modalities and some of the existing fusion approaches, suggesting that fusion is a viable approach that deserves further study and consideration.

In printed stylized documents, text lines may be curved in shape and as a result characters of a single line may be multi-oriented. This paper presents a multi-scale and multi-oriented character recognition scheme using foreground as well as background information. Here each character is partitioned into multiple circular zones. For each zone, three centroids are computed by grouping the constituent character segments (components) of each zone into two clusters. As a result, we obtain one global centroid for all the components in the zone, and further two centroids for the two generated clusters. The above method is repeated for both foreground as well as background information. The features are generated by encoding the spatial distribution of these centroids by computing their relative angular information. These features are then fed into a SVM classifier. A PCA based feature selection phase has also been applied. Detailed experiments on Bangla and Devanagari datasets have been performed. It has been seen that the proposed methodology outperforms a recent competing method.

Automatic script identification from handwritten document images facilitates many important applications such as indexing, sorting and triage. A given Optical Character Recognition (OCR) system is typically trained on only a single script but for documents or collections containing different scripts, there must be some way to automatically identify the script prior to OCR. For Indic script research, some results have been reported in the literature but the task is far from solved. In this paper, we propose a word-level script identification technique for six handwritten Indic scripts- Bangla, Devanagari, Gurumukhi, Malayalam, Oriya Telugu and the Roman script. A set of 82 features has been designed using a combination of elliptical and polygonal approximation techniques. Our approach has been evaluated on a dataset of 7000 handwritten text words, using multiple classifiers. A Multi-Layer Perceptron (MLP) classifier was found to be the best classifier resulting in 95.35% accuracy. The result is progressive considering the complexities and shape variations of the Indic scripts.

This paper presents a new technique for user identification and recognition based on the fusion of hand geometric features of both hands without any pose restrictions. All the features are extracted from normalized left and right hand images. Fusion is applied at feature and also at decision level. Two probability-based algorithms are proposed for classification. The first algorithm computes the maximum probability for nearest three neighbors. The second algorithm determines the maximum probability of the number of matched features with respect to a thresholding on distances. Based on these two highest probabilities initial decisions are made. The final decision is considered according to the highest probability as calculated by the Dempster–Shafer theory of evidence. Depending on the various combinations of the initial decisions, three schemes are experimented with 201 subjects for identification and verification. The correct identification rate is found to be 99.5%, and the false acceptance rate (FAR) of 0.625% has been found during verification.

This paper presents a robust approach for recognition of thermal face images based on decision level fusion of 34 different region classifiers. The region classifiers concentrate on local variations. They use singular value decomposition (SVD) for feature extraction. Fusion of decisions of the region classifier is done by using majority voting technique. The algorithm is tolerant against false exclusion of thermal information produced by the presence of inconsistent distribution of temperature statistics which generally make the identification process difficult. The algorithm is extensively evaluated on UGC-JU thermal face database, and Terravic facial infrared database and the recognition performance are found to be 95.83% and 100%, respectively. A comparative study has also been made with the existing works in the literature.

In this paper one investigation has been done to find the optimum level of fusion to find a fused image from visual as well as thermal images. Because of the use of face recognition system in critical areas like, authenticating an authorized person in highly secured areas, investigation of criminals, online monitoring etc, face recognition system should be very robust and accurate one. This work is an attempt to fuse visual and thermal face images at optimum level to extract the advantages of visual as well as thermal images. In our work, Object Tracking and Classification Beyond Visible Spectrum (OTCBVS) database has been used for the visual and thermal images. Among all the experiments a maximum recognition result obtained is 93%.

A rule-based expert system which uses generalized modus ponens (GMP) from fuzzy logic as a rule of inference is described here for classification of abnormalities related to rhythm disorder in the human heart, through interpretation of the patient's electrocardiographic (EGG) patterns. Application of GMP makes diagnosis of a wide range of variations in the input ECG patterns possible even if they differ from the patterns defined in the preconditions of the rules of the rulebase. The work shows how fuzzy logic with suitably drawn possibility distributions of variables of cardiological domain plays a significant role in making the expert system sensitive to finer variations of input ECG patterns, which are very common in bioelectric signals, without enhancing the size of the rulebase.