Single-cell Hi-C (scHi-C) provides unprecedented insight into 3D genome organization, but its sparse and noisy data pose challenges in accurately detecting A/B compartments, which are crucial for understanding chromatin structure and gene regulation. We presented scDIAGRAM, a data-driven method for annotating A/B compartments in single cells using direct statistical modeling and graph community detection. Unlike existing approaches, scDIAGRAM infers chromatin compartments directly from individual scHi-C matrix without imputation or external reference features, and subsequently assigns A/B labels using conventional genomic annotations. Accuracy and robustness of scDIAGRAM were illustrated through simulated scHi-C datasets and a human cell line. We applied scDIAGRAM to real scHi-C datasets from the mouse brain cortex, mouse embryonic development, and human acute myeloid leukemia, demonstrating its ability to capture compartmental shifts associated with transcriptional variation. This robust framework offers new insights into the functional roles of chromatin compartments at single-cell resolution across various biological contexts.

Integrated sensing and communication (ISAC) is expected to play a crucial role in the sixth-generation (6G) mobile communication systems, offering potential applications in the scenarios of intelligent transportation, smart factories, etc. The performance of radar sensing in ISAC systems is closely related to the characteristics of radar sensing and communication channels. Therefore, ISAC channel modeling serves as a fundamental cornerstone for evaluating and optimizing ISAC systems. This article provides a comprehensive survey on the ISAC channel modeling methods. Furthermore, the methods of target radar cross section (RCS) modeling and clutter RCS modeling are summarized. Finally, we discuss the future research trends related to ISAC channel modeling in various scenarios.

Identifying an appropriate radius for unbiased kernel estimation is crucial for the efficiency of radiance estimation. However, determining both the radius and unbiasedness still faces big challenges. In this paper, we first propose a statistical model of photon samples and associated contributions for progressive kernel estimation, under which the kernel estimation is unbiased if the null hypothesis of this statistical model stands. Then, we present a method to decide whether to reject the null hypothesis about the statistical population (i.e., photon samples) by the F-test in the Analysis of Variance. Hereby, we implement a progressive photon mapping (PPM) algorithm, wherein the kernel radius is determined by this hypothesis test for unbiased radiance estimation. Second, we propose VCM+, a reinforcement of Vertex Connection and Merging (VCM), and derive its theoretically unbiased formulation. VCM+ combines hypothesis testing-based PPM with bidirectional path tracing (BDPT) via multiple importance sampling (MIS), wherein our kernel radius can leverage the contributions from PPM and BDPT. We test our new algorithms, improved PPM and VCM+, on diverse scenarios with different lighting settings. The experimental results demonstrate that our method can alleviate light leaks and visual blur artifacts of prior radiance estimate algorithms. We also evaluate the asymptotic performance of our approach and observe an overall improvement over the baseline in all testing scenarios.

We present a novel chi-squared progressive photon mapping algorithm (CPPM) that constructs an estimator by controlling the bandwidth to obtain superior image quality. Our estimator has parametric statistical advantages over prior nonparametric methods. First, we show that when a probability density function of the photon distribution is subject to uniform distribution, the radiance estimation is unbiased under certain assumptions. Next, the local photon distribution is evaluated via a chi-squared test to determine whether the photons follow the hypothesized distribution (uniform distribution) or not. If the statistical test deems that the photons inside the bandwidth are uniformly distributed, bandwidth reduction should be suspended. Finally, we present a pipeline with a bandwidth retention and conditional reduction scheme according to the test results. This pipeline not only accumulates sufficient photons for a reliable chi-squared test, but also guarantees that the estimate converges to the correct solution under our assumptions. We evaluate our method on various benchmarks and observe significant improvement in the running time and rendering quality in terms of mean squared error over prior progressive photon mapping methods.

Multi-task learning aims at combining information across tasks to boost prediction performance, especially when the number of training samples is small and the number of predictors is very large. In this paper, we first extend the Sparse Discriminate Analysis (SDA) of Clemmensen et al.. We call this Multi-task Sparse Discriminate Analysis (MtSDA). MtSDA formulates multi-label prediction as a quadratic optimization problem whereas SDA obtains single labels via a nearest class mean rule. Second, we propose a class of equicorrelation matrices to use in MtSDA which includes the identity matrix. MtSDA with both matrices are compared with singletask learning (SVM and LDA+SVM) and multi-task learning (HSML). The comparisons are made on real data sets in terms of AUC and F-measure. The data results show that MtSDA outperforms other methods substantially almost all the time and in some cases MtSDA with the equicorrelation matrix substantially outperforms MtSDA with identity matrix.

Predicting the execution time of computer programs is an important but challenging problem in the community of computer systems. Existing methods require experts to perform detailed analysis of program code in order to construct predictors or select important features. We recently developed a new system to automatically extract a large number of features from program execution on sample inputs, on which prediction models can be constructed without expert knowledge. In this paper we study the construction of predictive models for this problem. We propose the SPORE (Sparse POlynomial REgression) methodology to build accurate prediction models of program performance using feature data collected from program execution on sample inputs. Our two SPORE algorithms are able to build relationships between responses (e.g., the execution time of a computer program) and features, and select a few from hundreds of the retrieved features to construct an explicitly sparse and non-linear model to predict the response variable. The compact and explicitly polynomial form of the estimated model could reveal important insights into the computer program (e.g., features and their non-linear combinations that dominate the execution time), enabling a better understanding of the program’s behavior. Our evaluation on three widely used computer programs shows that SPORE methods can give accurate prediction with relative error less than 7% by using a moderate number of training data samples. In addition, we compare SPORE algorithms to state-of-the-art sparse regression algorithms, and show that SPORE methods, motivated by real applications, outperform the other methods in terms of both interpretability and prediction accuracy.