Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, current experimental methods are costly and time-consuming. Computational approaches, while progressing, faced limitations due to insufficient structural data and the absence of a standardized protocol. To tackle these challenges, our lab previously developed IsAb1.0, an in silico antibody design protocol. Yet, IsAb1.0 lacked accuracy, had a complex procedure, and required extensive antibody bioinformation. Moreover, it overlooked nanobody and humanized antibody design, hindering therapeutic antibody development. Building upon IsAb1.0, we enhanced our design protocol with artificial intelligence methods to create IsAb2.0. IsAb2.0 utilized AlphaFold-Multimer (2.3/3.0) for accurate modeling and complex construction without templates and employed the precise FlexddG method for in silico antibody optimization. Validated through optimization of a humanized nanobody J3 (HuJ3) targeting HIV-1 gp120, IsAb2.0 predicted five mutations that can improve HuJ3-gp120 binding affinity. These predictions were confirmed by commercial software and validated through binding and neutralization assays. IsAb2.0 streamlined antibody design, offering insights into future techniques to accelerate immunotherapy development.

Dynamic neural network is an emerging research topic in deep learning. With adaptive inference, dynamic models can achieve remarkable accuracy and computational efficiency. However, it is challenging to design a powerful dynamic detector, because of no suitable dynamic architecture and exiting criterion for object detection. To tackle these difficulties, we propose a dynamic framework for object detection, named DynamicDet. Firstly, we carefully design a dynamic architecture based on the nature of the object detection task. Then, we propose an adaptive router to analyze the multi-scale information and to decide the inference route automatically. We also present a novel optimization strategy with an exiting criterion based on the detection losses for our dynamic detectors. Last, we present a variable-speed inference strategy, which helps to realize a wide range of accuracy-speed trade-offs with only one dynamic detector. Extensive experiments conducted on the COCO benchmark demonstrate that the proposed DynamicDet achieves new state-of-the-art accuracy-speed trade-offs. For instance, with comparable accuracy, the inference speed of our dynamic detector Dy-YOLOv7-W6 surpasses YOLOv7-E6 by 12%, YOLOv7-D6 by 17%, and YOLOv7-E6E by 39%. The code is available at https://github.com/VDIGPKU/DynamicDet.

Scene text recognition (STR) is a challenging problem due to the imperfect imagery conditions in natural images. State-of-the-art methods utilize both visual cues and linguistic knowledge to tackle this challenging problem. Specifically, they propose iterative language modeling module (IterLM) to repeatedly refine the output sequence from the visual modeling module (VM). Though achieving promising results, the vision modeling module has become the performance bottleneck of these methods. In this paper, we newly propose iterative vision modeling module (IterVM) to further improve the STR accuracy. Specifically, the first VM directly extracts multi-level features from the input image, and the following VMs re-extract multi-level features from the input image and fuse them with the high-level (i.e., the most semantic one) feature extracted by the previous VM. By combining the proposed IterVM with iterative language modeling module, we further propose a powerful scene text recognizer called IterNet. Extensive experiments demonstrate that the proposed IterVM can significantly improve the scene text recognition accuracy, especially on low-quality scene text images. Moreover, the proposed scene text recognizer IterNet achieves new state-of-the-art results on several public benchmarks. Codes and models are available at https://github.com/VDIGPKU/IterNet.

top-performing object detectors depend heavily on backbone networks, whose advances bring consistent performance gains through exploring more effective network structures. In this paper, we propose a novel and flexible backbone framework, namely CBNet, to construct high-performance detectors using existing open-source pre-trained backbones under the pre-training fine-tuning paradigm. In particular, CBNet architecture groups multiple identical backbones, which are connected through composite connections. Specifically, it integrates the high- and low-level features of multiple identical backbone networks and gradually expands the receptive field to more effectively perform object detection. We also propose a better training strategy with auxiliary supervision for CBNet-based detectors. CBNet has strong generalization capabilities for different backbones and head designs of the detector architecture. Without additional pre-training of the composite backbone, CBNet can be adapted to various backbones (i.e., CNN-based vs. Transformer-based) and head designs of most mainstream detectors (i.e., one-stage vs. two-stage, anchor-based vs. anchor-free-based). Experiments provide strong evidence that, compared with simply increasing the depth and width of the network, CBNet introduces a more efficient, effective, and resource-friendly way to build high-performance backbone networks. Particularly, our CB-Swin-L achieves 59.4% box AP and 51.6% mask AP on COCO test-dev under the single-model and single-scale testing protocol, which are significantly better than the state-of-the-art results (i.e., 57.7% box AP and 50.2% mask AP) achieved by Swin-L, while reducing the training time by 6×. With multi-scale testing, we push the current best single model result to a new record of 60.1% box AP and 52.3% mask AP without using extra training data. Code is available at https://github.com/VDIGPKU/CBNetV2.