Peiqi Wang, ShengYun Peng, Xuewen Zhang, Hanchao Yu, Yibo Yang, Lifu Huang, Fujun Liu, Qifan Wang. Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2025.

Idiopathic inflammatory myopathy (IIM) is a common skeletal muscle disease that relates to weakness and inflammation of muscle. Early diagnosis and prognosis of different types of IIMs will guide the effective treatment. Interpretation of digitized images of the cross-section muscle biopsy, which is currently done manually, provides the most reliable diagnostic information. With the increasing volume of images, the management and manual interpretation of the digitized muscle images suffer from low efficiency and high interobserver variabilities. In order to address these problems, we propose the first complete framework of automatic IIM diagnosis system for the management and interpretation of digitized skeletal muscle histopathology images. The proposed framework consists of several key components: (1) Automatic cell segmentation, perimysium annotation, and nuclei detection; (2) histogram-based feature extraction and quantification; (3) content-based image retrieval to search and retrieve similar cases in the database for comparative study; and (4) majority voting-based classification to provide decision support for computer-aided clinical diagnosis. Experiments show that the proposed diagnosis system provides efficient and robust interpretation of the digitized muscle image and computer-aided diagnosis of IIM.

Computerized microscopy image analysis plays an important role in computer aided diagnosis and prognosis. Machine learning techniques have powered many aspects of medical investigation and clinical practice. Recently, deep learning is emerging as a leading machine learning tool in computer vision and has attracted considerable attention in biomedical image analysis. In this paper, we provide a snapshot of this fast-growing field, specifically for microscopy image analysis. We briefly introduce the popular deep neural networks and summarize current deep learning achievements in various tasks, such as detection, segmentation, and classification in microscopy image analysis. In particular, we explain the architectures and the principles of convolutional neural networks, fully convolutional networks, recurrent neural networks, stacked autoencoders, and deep belief networks, and interpret their formulations or modelings for specific tasks on various microscopy images. In addition, we discuss the open challenges and the potential trends of future research in microscopy image analysis using deep learning.

Previous work has introduced probability distributions as first-class components in uncertain stream database systems. A lacking element is the fact of how accurate these probability distributions are. This indeed has a profound impact on the accuracy of query results presented to end users. While there is some previous work that studies unreliable intermediate query results in the tuple uncertainty model, to the best of our knowledge, we are the first to consider an uncertain stream database in which accuracy is taken into consideration all the way from the learned distributions based on raw data samples to the query results. We perform an initial study of various components in an accuracy-aware uncertain stream database system, including the representation of accuracy information and how to obtain query results' accuracy. In addition, we propose novel predicates based on hypothesis testing for decision-making using data with limited accuracy. We augment our study with a comprehensive set of experimental evaluations.