We present a novel multiresolution scheme for the detection of spiculated lesions in digital mammograms. First, a multiresolution representation of the original mammogram is obtained using a linear phase nonseparable two-dimensional (2-D) wavelet transform. A set of features is then extracted at each resolution in the wavelet pyramid for every pixel. This approach addresses the difficulty of predetermining the neighborhood size for feature extraction to characterize objects that may appear in different sizes. Detection is performed from the coarsest resolution to the finest resolution using a binary tree classifier. This top-down approach requires less computation by starting with the least amount of data and propagating detection results to finer resolutions. Experimental results using the MIAS image database have shown that this algorithm is capable of detecting spiculated lesions of very different sizes at low false positive rates.

Presents a novel approach to the problem of computer aided analysis of digital mammograms for breast cancer detection: namely, the development of algorithms to recognize unequivocally normal mammograms. First, the authors eliminate amorphous "clouds" or "blobs" in mammograms produced by normal glandular tissue of varying density using local average subtraction. Then the authors identify and remove normal connective tissue markings based on a set of specially designed line detectors. Any abnormality that may exist in the mammogram is therefore enhanced in the residual image, which makes the decision regarding the normality of the mammogram, much easier.

Recently, there has been a great increase in interest in using three dimensional stereoscopic displays to provide viewers with realistic 3D views of objects of interest. Some applications where stereoscopic displays are becoming popular include medical visualization, visualization of meteorological data, and various virtual reality applications. To quantify the effectiveness of stereoscopic systems over conventional monoscopic systems, well-designed experiments and data analysis methods are necessary. This task requires the combined effort of application scientists and experts in experimental design. Lack of interdisciplinary collaboration is a primary weakness of many stereoscopic display studies, resulting in the neglect of many important but subtle experimental issues. In this paper, we discuss specific issues that arise in the design of studies to determine the effectiveness of digital stereo imagery. Issues concerning statistical analysis of the experimental data are also discussed. References to related literature from engineering, computer graphics, and psychophysics are given. The issues developed herein provide a guideline for the design of studies to compare observer performance when using different imaging modalities.

Reports the diagnostic performance of observers in detecting abnormalities in computer-generated mammogram-like images. A mathematical model of the human breast is defined in which breast tissues are simulated by spheres of different sizes and densities. Images are generated by casting rays from a specified source, through the model, and onto an image plane. Observer performance when using two viewing modalities (stereo versus mono) is compared. In the stereo viewing mode, images are presented to the observer (wearing liquid-crystal display glasses), such that the left eye sees the left image only and the right eye sees the right image only. In this way, the images can be fused by the observer to obtain a sense of depth. In the mono viewing mode, identical images are presented to the left and right eyes so that no binocular disparities will be produced by the images. Observer response data are evaluated using receiver operating characteristic (ROC) analysis to characterize any difference in detectability of abnormalities (in either the density or the arrangement of simulated tissue densities) using the two viewing modes. The authors' experimental results indicate the clear superiority of stereo viewing for detection of arrangement abnormalities. For detection of density abnormalities, the performance of the two viewing modes is similar. These preliminary results suggest that stereomammography may permit easier detection of certain tissue abnormalities, perhaps providing a route to earlier tumor detection in cases of breast cancer.