Page placement is a critical problem for memory-intensive applications running on a shared-memory multiprocessor with a non-uniform memory access (NUMA) architecture. State-of-the-art page placement mechanisms interleave pages evenly across NUMA nodes. However, this approach fails to maximize memory throughput in modern NUMA systems, characterized by asymmetric bandwidths and latencies, and sensitive to memory contention and interconnect congestion phenomena.We propose BWAP, a novel page placement mechanism based on asymmetric weighted page interleaving. BWAP combines an analytical performance model of the target NUMA system with on-line iterative tuning of page distribution for a given memory-intensive application. Our experimental evaluation with representative memory-intensive workloads shows that BWAP performs up to 66% better than state-of-the-art techniques. These gains are particularly relevant when multiple co-located applications run in disjoint partitions of a large NUMA machine or when applications do not scale up to the total number of cores.

The growing pressure on cloud application scalability has accentuated storage performance as a critical bottleneck. Although cache replacement algorithms have been extensively studied, cache prefetching - reducing latency by retrieving items before they are actually requested - remains an underexplored area. Existing approaches to history-based prefetching, in particular, provide too few benefits for real systems for the resources they cost.

The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to the transport process is the hydrophobic interactions between karyopherins (kaps) and Phe-Gly (FG) repeat domains. Taking into account the polymeric nature of FG-repeats grafted on the elastic structure of the NPC, and the kap-FG hydrophobic affinity, we have established a coarse-grained model of the NPC structure that mimics nucleocytoplasmic transport. To establish a foundation for future works, the methodology and biophysical rationale behind the model is explained in details. The model predicts that the first-passage time of a 15 nm cargo-complex is about 2.6±0.13 ms with an inverse Gaussian distribution for statistically adequate number of independent Brownian dynamics simulations. Moreover, the cargo-complex is primarily attached to the channel wall where it interacts with the FG-layer as it passes through the central channel. The kap-FG hydrophobic interaction is highly dynamic and fast, which ensures an efficient translocation through the NPC. Further, almost all eight hydrophobic binding spots on kap-β are occupied simultaneously during transport. Finally, as opposed to intact NPCs, cytoplasmic filaments-deficient NPCs show a high degree of permeability to inert cargos, implying the defining role of cytoplasmic filaments in the selectivity barrier.