MOTIVATION: Spatial transcriptomics (ST) technologies measure gene expression together with spatial locations, but each spot typically contains a mixture of cell types, posing a challenge for downstream analysis. Cell-type deconvolution aims to infer spot-wise cell-type proportions by integrating single-cell RNA-seq (scRNA-seq) and ST data. Many existing methods construct cell-type signatures from predefined marker genes, which can limit performance when marker information is incomplete or unavailable. RESULTS: To address this limitation, we propose a spatial-aware auto-encoder framework (SA2E) for cell-type deconvolution without requiring predefined cell-type biomarkers. SA2E learns latent spot representations using a spatially regularized auto-encoder that preserves the local topology of the spot spatial graph. Based on these representations, SA2E learns cell-type signatures by enforcing them to reconstruct ST expression. In our framework, simulated ST data with known proportions are used for supervised pretraining, while real ST data are optimized using the reconstruction objective. Extensive experiments on simulated and real ST datasets demonstrate that SA2E outperforms state-of-the-art deconvolution baselines. AVAILABILITY AND IMPLEMENTATION: The code of SA2E is available at Github (https://github.com/xkmaxidian/SA2E) and Zenodo (DOI: 10.5281/zenodo.18765467).

Abstract Image restoration poses a significant challenge, aiming to accurately recover damaged images by delving into their inherent characteristics. Various models and algorithms have been explored by researchers to address different types of image distortions, including sparse representation, grouped sparse representation, and low‐rank self‐representation. The grouped sparse representation algorithm leverages the prior knowledge of non‐local self‐similarity and imposes sparsity constraints to maintain texture information within images. To further exploit the intrinsic properties of images, this study proposes a novel low‐rank representation‐guided grouped sparse representation image restoration algorithm. This algorithm integrates self‐representation models and trace optimization techniques to effectively preserve the original image structure, thereby enhancing image restoration performance while retaining the original texture and structural information. The proposed method was evaluated on image denoising and deblocking tasks across several datasets, demonstrating promising results.

Abstract Image restoration, as a fundamental research topic of image processing, is to reconstruct the original image from degraded signal using the prior knowledge of image. Group sparse representation (GSR) is powerful for image restoration; it however often leads to undesirable sparse solutions in practice. In order to improve the quality of image restoration based on GSR, the sparsity residual model expects the representation learned from degraded images to be as close as possible to the true representation. In this article, a group residual learning based on low‐rank self‐representation is proposed to automatically estimate the true group sparse representation. It makes full use of the relation among patches and explores the subgroup structures within the same group, which makes the sparse residual model have better interpretation furthermore, results in high‐quality restored images. Extensive experimental results on two typical image restoration tasks (image denoising and deblocking) demonstrate that the proposed algorithm outperforms many other popular or state‐of‐the‐art image restoration methods.

BACKGROUND: Drug combination, offering an insight into the increased therapeutic efficacy and reduced toxicity, plays an essential role in the therapy of many complex diseases. Although significant efforts have been devoted to the identification of drugs, the identification of drug combination is still a challenge. The current algorithms assume that the independence of feature selection and drug prediction procedures, which may result in an undesirable performance. RESULTS: To address this issue, we develop a novel Semi-supervised Heterogeneous Network Embedding algorithm (called SeHNE) to predict the combination patterns of drugs by exploiting the graph embedding. Specifically, the ATC similarity of drugs, drug-target, and protein-protein interaction networks are integrated to construct the heterogeneous networks. Then, SeHNE jointly learns drug features by exploiting the topological structure of heterogeneous networks and predicting drug combination. One distinct advantage of SeHNE is that features of drugs are extracted under the guidance of classification, which improves the quality of features, thereby enhancing the performance of prediction of drugs. Experimental results demonstrate that the proposed algorithm is more accurate than state-of-the-art methods on various data, implying that the joint learning is promising for the identification of drug combination. CONCLUSIONS: The proposed model and algorithm provide an effective strategy for the prediction of combinatorial patterns of drugs, implying that the graph-based drug prediction is promising for the discovery of drugs.

Abstract In this paper, a method of detecting flame from video stream is proposed exploiting the characteristics of the disordered movement, rapid deformation and intense colour of the flame. Firstly, the frame difference between video frame and background frame is calculated to obtain the main part of the moving object, and the difference between frames is calculated frame by frame in time series to obtain the deformation part of the moving object, and then the sum of cumulative difference between frames and the background difference between frames are added to generate a binary image containing the moving object and the deformed part. Secondly, the binary image is morphologically opened, and rectangular segmentation is carried out to obtain multiple suspicious flame regions. Finally, in the light of the intense colour of the flame, the corresponding area is extracted from the original picture by using the segmentation rectangle, and the colour statistics of the area are carried out to further judge whether there is a burning flame in the area. The experimental results show that the algorithm can accurately detect the burning area of flame in the real scene and eliminate the light interference and the movement interference.