An effort is made herein to demonstrate advanced terrain motion products obtained via operational SAR interferometric services running on the Geohazards Exploitation Platform to support the World Bank's City Resilience Program. The objective is to highlight the validity of medium resolution terrain motion products for the provision of systematic terrain motion analysis to operational teams, allowing for the prompt identification of potential hazardous phenomena over wide areas. The challenge is to inform the City Resilience Program and its connected operational teams about urban hazards in a rapid manner in order to capably guide their investment plans in resilience. Such services, combined with tailored capacity building activities, pave the way for the use of a platform-based InSAR solution directly by EO practitioners and end-users for the purpose of monitoring cities according to various concerns. The introduction of online tools expands and scales the skills of technical staff of local authorities and relevant agencies while increasing their acceptance of Earth Observation and its solutions.

MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

MOTIVATION: Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are important for the scientific community. RESULTS: We developed a web version of the G4Hunter application. This new web-based server is a platform-independent and user-friendly application for quadruplex analyses. It allows retrieval of gene/nucleotide sequence entries from NCBI databases and provides complete characterization of localization and quadruplex propensity of quadruplex-forming sequences. The G4Hunter web application includes an interactive graphical data representation with many useful options including visualization, sorting, data storage and export. AVAILABILITY AND IMPLEMENTATION: G4Hunter web application can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.