Quantum computers promise significant advantages over classical computers for a number of different applications. We show that the complete loss function landscape of a neural network can be represented as the quantum state output by a quantum computer. We demonstrate this explicitly for a binary neural network and, further, show how a quantum computer can train the network by manipulating this state using a well-known algorithm known as quantum amplitude amplification. We further show that with minor adaptation, this method can also represent the meta-loss landscape of a number of neural network architectures simultaneously. We search this meta-loss landscape with the same method to simultaneously train and design a binary neural network.

Schaefer introduced a framework for generalized satisfiability problems on the Boolean domain and characterized the computational complexity of such problems. We investigate an algebraization of Schaefer's framework in which the Fourier transform is used to represent constraints by multilinear polynomials in a unique way. This representation of constraints gives rise to a relaxation of the notion of satisfiability in which the values to variables are linear operators on some Hilbert space. For constraints given by a system of linear equations over the two-element field, earlier work in the foundations of quantum mechanics has shown that there are systems that have no solutions in the Boolean domain, but have solutions via operator assignments on some finite-dimensional Hilbert space. Our main result is a complete characterization of the classes of Boolean relations for which there is a gap between satisfiability in the Boolean domain and the relaxation of satisfiability via operator assignments.

We introduce a nonlocal game that captures and extends the notion of graph isomorphism. This game can be won in the classical case if and only if the two input graphs are isomorphic. Thus, by considering quantum strategies we are able to define the notion of quantum isomorphism. We also consider the case of more general non-signalling strategies, and show that such a strategy exists if and only if the graphs are fractionally isomorphic. We prove several necessary conditions for quantum isomorphism, including cospectrality, and provide a construction for producing pairs of non-isomorphic graphs that are quantum isomorphic. We then show that both classical and quantum isomorphism can be reformulated as feasibility programs over the completely positive and completely positive semidefinite cones respectively. This leads us to considering relaxations of (quantum) isomorphism arrived at by relaxing the cone to either the doubly nonnegative (DNN) or positive semidefinite (PSD) cones. We show that DNN-isomorphism is equivalent to the previous defined notion of graph equivalence, a polynomial-time decidable relation that is related to coherent algebras. We also show that PSD-isomorphism implies several types of cospectrality, and that it is equivalent to cospectrality for connected 1-walk-regular graphs. Finally, we show that all of the above mentioned relations form a strict hierarchy of weaker and weaker relations, with non-singalling/fractional isomorphism being the weakest. The techniques used are an interesting mix of algebra, combinatorics, and quantum information.

We initiate the study of zero-error communication via quantum channels when the receiver and the sender have at their disposal a noiseless feedback channel of unlimited quantum capacity, generalizing Shannon's zero-error communication theory with instantaneous feedback. We first show that this capacity is only a function of the linear span of Choi-Kraus operators of the channel, which generalizes the bipartite equivocation graph of a classical channel, and which we dub non-commutative bipartite graph. Then, we go on to show that the feedback-assisted capacity is non-zero (allowing for a constant amount of activating noiseless communication) if and only if the non-commutative bipartite graph is non-trivial, and give a number of equivalent characterizations. This result involves a far-reaching extension of the conclusive exclusion of quantum states. We then present an upper bound on the feedback-assisted zero-error capacity, motivated by a conjecture originally made by Shannon and proved later by Ahlswede. We demonstrate that this bound to have many good properties, including being additive and given by a minimax formula. We also prove a coding theorem showing that this quantity is the entanglement-assisted capacity against an adversarially chosen channel from the set of all channels with the same Choi-Kraus span, which can also be interpreted as the feedback-assisted unambiguous capacity. The proof relies on a generalization of the Postselection Lemma (de Finetti reduction) that allows to reflect additional constraints, and which we believe to be of independent interest. This capacity is a relaxation of the feedback-assisted zero-error capacity; however, we have to leave open the question of whether they coincide in general. We illustrate our ideas with a number of examples, including classical-quantum channels and Weyl diagonal channels, and close with an extensive discussion of open questions.

We design logic circuits based on the notion of zero forcing on graphs; each gate of the circuits is a gadget in which zero forcing is performed. We show that such circuits can evaluate every monotone Boolean function. By using two vertices to encode each logical bit, we obtain universal computation. We also highlight a phenomenon of "back forcing" as a property of each function. Such a phenomenon occurs in a circuit when the input of gates which have been already used at a given time step is further modified by a computation actually performed at a later stage. Finally, we show that zero forcing can be also used to implement reversible computation. The model introduced here provides a potentially new tool in the analysis of Boolean functions, with particular attention to monotonicity. Moreover, in the light of applications of zero forcing in quantum mechanics, the link with Boolean functions may suggest a new directions in quantum control theory and in the study of engineered quantum spin systems. It is an open technical problem to verify whether there is a link between zero forcing and computation with contact circuits.

The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour heterogeneity, the diversity of the cancer cell population within the tumour of an individual patient, is related to cancer stem cells and is also considered a potential prognostic indicator in oncology. The measurement of cancer stem cell abundance and intra-tumour heterogeneity in a clinically relevant manner however, currently presents a challenge. Here we propose signalling entropy, a measure of signalling pathway promiscuity derived from a sample's genome-wide gene expression profile, as an estimate of the stemness of a tumour sample. By considering over 500 mixtures of diverse cellular expression profiles, we reveal that signalling entropy also associates with intra-tumour heterogeneity. By analysing 3668 breast cancer and 1692 lung adenocarcinoma samples, we further demonstrate that signalling entropy correlates negatively with survival, outperforming leading clinical gene expression based prognostic tools. Signalling entropy is found to be a general prognostic measure, valid in different breast cancer clinical subgroups, as well as within stage I lung adenocarcinoma. We find that its prognostic power is driven by genes involved in cancer stem cells and treatment resistance. In summary, by approximating both stemness and intra-tumour heterogeneity, signalling entropy provides a powerful prognostic measure across different epithelial cancers.

We study zero-error entanglement-assisted source-channel coding (communication in the presence of side information). Adapting a technique of Beigi, we show that such coding requires existence of a set of vectors satisfying orthogonality conditions related to suitably defined graphs G and H. Such vectors exist if and only if ϑ(G̅) ≤ ϑ(H̅), where ϑ represents the Lovász number. We also obtain similar inequalities for the related Schrijver ϑ-and Szegedy ϑ+numbers. These inequalities reproduce several known bounds and also lead to new results. We provide a lower bound on the entanglement-assisted cost rate. We show that the entanglement-assisted independence number is bounded by the Schrijver number: α*(G) ≤ ϑ-(G). Therefore, we are able to disprove the conjecture that the one-shot entanglement-assisted zero-error capacity is equal to the integer part of the Lovász number. Beigi introduced a quantity β as an upper bound on α* and posed the question of whether β(G) = ⌊ϑ(G)⌋. We answer this in the affirmative and show that a related quantity is equal to ⌊ϑ(G)⌋. We show that a quantity χvect(G) recently introduced in the context of Tsirelson's problem is equal to ⌊ϑ+(G)⌋. In an appendix, we investigate multiplicativity properties of Schrijver's and Szegedy's numbers, as well as projective rank.

We study the quantum channel version of Shannon's zero-error capacity problem. Motivated by recent progress on this question, we propose to consider a certain subspace of operators (so-called operator systems) as the quantum generalization of the adjacency matrix, in terms of which the zero-error capacity of a quantum channel, as well as the quantum and entanglement-assisted zero-error capacities can be formulated, and for which we show some new basic properties. Most importantly, we define a quantum version of Lovász' famous ϑ function on general operator systems, as the norm-completion (or stabilization) of a “naive” generalization of ϑ. We go on to show that this function upper bounds the number of entanglement-assisted zero-error messages, that it is given by a semidefinite program, whose dual we write down explicitly, and that it is multiplicative with respect to the tensor product of operator systems (corresponding to the tensor product of channels). We explore various other properties of the new quantity, which reduces to Lovász' original ϑ in the classical case, give several applications, and propose to study the operator systems associated with channels as “noncommutative graphs,” using the language of Hilbert modules.

We introduce two generalizations of Kochen-Specker (KS) sets: projective KS sets and generalized KS sets. We then use projective KS sets to characterize all graphs for which the chromatic number is strictly larger than the quantum chromatic number. Here, the quantum chromatic number is defined via a nonlocal game based on graph coloring. We further show that from any graph with separation between these two quantities, one can construct a classical channel for which entanglement assistance increases the one-shot zero-error capacity. As an example, we exhibit a new family of classical channels with an exponential increase.

The quantum chromatic number of a graph G is sandwiched between its chromatic number and its clique number, which are well-known NP-hard quantities. We restrict our attention to the rank-1 quantum chromatic number χq(1)(G), which upper bounds the quantum chromatic number, but is defined under stronger constraints. We study its relation with the chromatic number χ(G) and the minimum dimension of orthogonal representations ξ(G). It is known that ξ(G) ≤ χq(1)(G) ≤ χ(G). We answer three open questions about these relations: we give a necessary and sufficient condition to have ξ(G) = χq(1)(G), we exhibit a class of graphs such that ξ(G) ≤ χq(1)(G), and we give a necessary and sufficient condition to have χq(1)(G) ≤ χ(G). Our main tools are Kochen-Specker sets, collections of vectors with a traditionally important role in the study of contextuality of physical theories and, more recently, in the quantification of quantum zero-error capacities. Finally, as a corollary of our results and a result by Avis et al on the quantum chromatic number, we give a family of Kochen-Specker sets of growing dimension.

We study the quantum channel version of Shannon's zero-error capacity problem. Motivated by recent progress on this question, we propose to consider a certain linear space operators as the quantum generalisation of the adjacency matrix, in terms of which the plain, quantum and entanglement-assisted capacity can be formulated, and for which we show some new basic properties. Most importantly, we define a quantum version of Lovász' famous υ function, as the norm-completion (or stabilisation) of a “naive” generalisation of υ. We go on to show that this function upper bounds the number of entanglement-assisted zero-error messages, that it is given by a semidefinite programme, whose dual we write down explicitly, and that it is multiplicative with respect to the natural (strong) graph product. We explore various other properties of the new quantity, which reduces to Lovász' original υ in the classical case, give several applications, and propose to study the linear spaces of operators associated to channels as “non-commutative graphs”, using the language of operator systems and Hilbert modules.

The density matrices of graphs are combinatorial laplacians normalised to have trace one (Braunsteinet al. 2006b). If the vertices of a graph are arranged as an array, its density matrix carries a block structure with respect to which properties such as separability can be considered. We prove that the so-called degree-criterion, which was conjectured to be necessary and sufficient for the separability of density matrices of graphs, is equivalent to the PPT-criterion. As such, it is not sufficient for testing the separability of density matrices of graphs (we provide an explicit example). Nonetheless, we prove the sufficiency when one of the array dimensions has length two (see Wu (2006) for an alternative proof). Finally, we derive a rational upper bound on the concurrence of density matrices of graphs and show that this bound is exact for graphs on four vertices.