Dementia and mild cognitive impairment (MCI) represent significant health challenges in an aging population. As the search for noninvasive, precise and accessible diagnostic methods continues, the efficacy of electroencephalography (EEG) combined with deep convolutional neural networks (DCNNs) in varied clinical settings remains unverified, particularly for pathologies underlying MCI such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and idiopathic normal-pressure hydrocephalus (iNPH). Addressing this gap, our study evaluates the generalizability of a DCNN trained on EEG data from a single hospital (Hospital #1). For data from Hospital #1, the DCNN achieved a balanced accuracy (bACC) of 0.927 in classifying individuals as healthy (n = 69) or as having AD, DLB, or iNPH (n = 188). The model demonstrated robustness across institutions, maintaining bACCs of 0.805 for data from Hospital #2 (n = 73) and 0.920 at Hospital #3 (n = 139). Additionally, the model could differentiate AD, DLB, and iNPH cases with bACCs of 0.572 for data from Hospital #1 (n = 188), 0.619 for Hospital #2 (n = 70), and 0.508 for Hospital #3 (n = 139). Notably, it also identified MCI pathologies with a bACC of 0.715 for Hospital #1 (n = 83), despite being trained on overt dementia cases instead of MCI cases. These outcomes confirm the DCNN's adaptability and scalability, representing a significant stride toward its clinical application. Additionally, our findings suggest a potential for identifying shared EEG signatures between MCI and dementia, contributing to the field's understanding of their common pathophysiological mechanisms.

While loopy Belief Propagation (LBP) has been utilized in a wide variety of applications with empirical success, it comes with few theoretical guarantees. Especially, if the interactions of random variables in a graphical model are strong, the behaviors of the algorithm can be difficult to analyze due to underlying phase transitions. In this paper, we develop a novel approach to the uniqueness problem of the LBP fixed point; our new “necessary and sufficient” condition is stated in terms of graphs and signs, where the sign denotes the types (attractive/repulsive) of the interaction (i.e., compatibility function) on the edge. In all previous works, uniqueness is guaranteed only in the situations where the strength of the interactions are “sufficiently” small in certain senses. In contrast, our condition covers arbitrary strong interactions on the specified class of signed graphs. The result of this paper is based on the recent theoretical advance in the LBP algorithm; the connection with the graph zeta function.

We propose a new approach to the analysis of Loopy Belief Propagation (LBP) by establishing a formula that connects the Hessian of the Bethe free energy with the edge zeta function. The formula has a number of theoretical implications on LBP. It is applied to give a sufficient condition that the Hessian of the Bethe free energy is positive definite, which shows non-convexity for graphs with multiple cycles. The formula clarifies the relation between the local stability of a fixed point of LBP and local minima of the Bethe free energy. We also propose a new approach to the uniqueness of LBP fixed point, and show various conditions of uniqueness.

This paper deals with audio-video transmission over IP networks and proposes a method of estimating perceptual QoS (i.e., user-level QoS) in real time in terms of the interval scale, which is referred to as the psychological scale. The proposed scheme utilizes both temporal and no reference spatial (picture's) quality, which are application-level QoS, and estimates the user-level QoS from the application-level QoS. To evaluate the effectiveness of the proposed scheme, we compare the proposed scheme with a scheme which uses only temporal quality for the estimation and a scheme with both temporal and Full Reference spatial quality. We made a simple experiment of audio-video IP transmission; we measured the application-level QoS directly and assessed the user-level QoS by the method of successive categories. Applying the principal component analysis and multiple regression analysis to the experimental results, we obtained multiple regression lines (i.e., equations for the estimation). As a result, we see that the user-level QoS can be estimated with high accuracy by using both temporal quality and spatial quality.