This paper proposes a scalable and straightforward pre-training paradigm for efficient visual conceptual representation called occluded image contrastive learning (OCL). Our OCL approach is simple: we randomly mask patches to generate different views within an image and contrast them among a mini-batch of images. The core idea behind OCL consists of two designs. First, masked tokens have the potential to significantly diminish the conceptual redundancy inherent in images, and create distinct views with substantial fine-grained differences on the semantic concept level instead of the instance level. Second, contrastive learning is adept at extracting high-level semantic conceptual features during the pre-training, circumventing the high-frequency interference and additional costs associated with image reconstruction. Importantly, OCL learns highly semantic conceptual representations efficiently without relying on hand-crafted data augmentations or additional auxiliary modules. Empirically, OCL demonstrates high scalability with Vision Transformers, as the ViT-L/16 can complete pre-training in 133 hours using only 4 A100 GPUs, achieving 85.8\% accuracy in downstream fine-tuning tasks. Code is available at https://github.com/XiaoyuYoung/OCL.

Segmentation of the coronary artery is an important task for the quantitative analysis of coronary computed tomography angiography (CCTA) images and is being stimulated by the field of deep learning. However, the complex structures with tiny and narrow branches of the coronary artery bring it a great challenge. Coupled with the medical image limitations of low resolution and poor contrast, fragmentations of segmented vessels frequently occur in the prediction. Therefore, a geometry-based cascaded segmentation method is proposed for the coronary artery, which has the following innovations: 1) Integrating geometric deformation networks, we design a cascaded network for segmenting the coronary artery and vectorizing results. The generated meshes of the coronary artery are continuous and accurate for twisted and sophisticated coronary artery structures, without fragmentations. 2) Different from mesh annotations generated by the traditional marching cube method from voxel-based labels, a finer vectorized mesh of the coronary artery is reconstructed with the regularized morphology. The novel mesh annotation benefits the geometry-based segmentation network, avoiding bifurcation adhesion and point cloud dispersion in intricate branches. 3) A dataset named CCA-200 is collected, consisting of 200 CCTA images with coronary artery disease. The ground truths of 200 cases are coronary internal diameter annotations by professional radiologists. Extensive experiments verify our method on our collected dataset CCA-200 and public ASOCA dataset, with a Dice of 0.778 on CCA-200 and 0.895 on ASOCA, showing superior results. Especially, our geometry-based model generates an accurate, intact and smooth coronary artery, devoid of any fragmentations of segmented vessels.

Real-world classification tasks often show an extremely imbalanced problem. The extreme imbalance will cause a strong bias that the decision boundary of the classifier is completely dominated by the categories with abundant samples, which are also called the head categories. Current methods have alleviated the imbalanced impact from mainly three aspects: class re-balance, decoupling and domain adaptation. However, the existing criterion with the winner-take-all strategy still leads to the crowding problem in the eigenspace. The head categories with many samples can extract features more accurately, but occupy most of the eigenspace. The tail categories sharing the rest of the narrow eigenspace are too crowded together to accurately extract features. Above these issues, we propose a novel T-distributed spherical metric for equalized eigenspace in the imbalanced classification, which has the following innovations: 1) We design the T-distributed spherical metric, which has the characteristics of high kurtosis. Instead of the winner-take-all strategy, the T-distributed spherical metric produces a high logit only when the extracted feature is close enough to the category center, without a strong bias against other categories. 2) The T-distributed spherical metric is integrated into the classifier, which is able to equalize the eigenspace for alleviating the crowding issue in the imbalanced problem. The equalized eigenspace by the T-distributed spherical classifier is capable of improving the accuracy of the tail categories while maintaining the accuracy of the head, which significantly promotes the intraclass compactness and interclass separability of features. Extensive experiments on large-scale imbalanced datasets verify our method, which shows superior results in the long-tailed CIFAR-100/-10 with the imbalanced ratio IR = 100/50. Our method also achieves excellent results on the large-scale ImageNet-LT dataset and the iNaturalist dataset with various backbones. In addition, we provide a case study of the real clinical classification of pancreatic tumor subtypes with 6 categories. Among them, the largest number of PDAC accounts for 315 cases, and the least CP has only 8 cases. After 4-fold cross-validation, we achieved a top-1 accuracy of 69.04%.

The cross-modality generation is usually a challenging task, especially for the medical image with a huge distribution difference. Micro Computed Tomography (Micro-CT) has high resolution and sharp contrast, which is regarded as the gold standard of tooth structure in dentistry. But Micro-CT has to scan a single isolated tooth in vitro, it cannot provide any information before surgery. Cone Beam Computed Tomography (CBCT) is commonly used in clinical treatment, but its low resolution and blurred border often lead to the deficiency of accurate tooth structure for surgery, such as the pulp and crown. The modality conversion from CBCT to Micro-CT is very difficult due to the huge difference between two modality distributions. Most GAN-based models cannot cope with such distribution differences between modalities. Therefore, we propose a novel cross-modality method for generating Micro-CT from CBCT. First, we propose a variation-based distance to reflect the difference between the two modality distributions. Second, integrating the variation-based distance, we design an end-to-end neural network named Variational Synthesis network (VSnet) to generate the Micro-CT from CBCT. Finally, we compare our method with plentiful state-of-the-art image generation methods. The results show that our proposed method is superior to other existing methods on the Micro-CT generation task, with image quality index SSIM of 0.912 $(\pm 0.061)$, PSNR of 22.451 $(\pm 4.810)$, and NRMSE of 0.261 $(\pm 0.142)$. In terms of the generation of the tooth structure, we also achieve superior results in clinic application. For the Micro-CT generated by VSnet, it is easy to achieve precise segmentations of tooth pulp and crown through simple thresholding, which facilitates the diagnosis in dental clinic.