Summary: We have developed a public Chemical In vitro–In vivo Profiling (CIIPro) portal, which can automatically extract in vitro biological data from public resources (i.e. PubChem) for user-supplied compounds. For compounds with in vivo target activity data (e.g. animal toxicity testing results), the integrated cheminformatics algorithm will optimize the extracted biological data using in vitro–in vivo correlations. The resulting in vitro biological data for target compounds can be used for read-across risk assessment of target compounds. Additionally, the CIIPro portal can identify the most similar compounds based on their optimized bioprofiles. The CIIPro portal provides new powerful assessment capabilities to the scientific community and can be easily integrated with other cheminformatics tools. Availability and Implementation: ciipro.rutgers.edu. Contact: [email protected] or [email protected]

The fabless model was traditionally enabled through clean interfaces - both in technical and business terms - between foundries and fabless semiconductor companies. However, with advanced geometry and analog/mixed-signal process nodes, the technical challenges have been greatly magnified, so that successful semiconductor design requires intimate co-optimization of design and manufacturing, infringing upon those clean interfaces. The panel presents views to these challenges and specifically how companies are planning to address them.