BACKGROUND: Centralized and federated models for sharing data in research networks currently exist. To build multivariate data analysis for centralized networks, transfer of patient-level data to a central computation resource is necessary. The authors implemented distributed multivariate models for federated networks in which patient-level data is kept at each site and data exchange policies are managed in a study-centric manner. OBJECTIVE: The objective was to implement infrastructure that supports the functionality of some existing research networks (e.g., cohort discovery, workflow management, and estimation of multivariate analytic models on centralized data) while adding additional important new features, such as algorithms for distributed iterative multivariate models, a graphical interface for multivariate model specification, synchronous and asynchronous response to network queries, investigator-initiated studies, and study-based control of staff, protocols, and data sharing policies. MATERIALS AND METHODS: Based on the requirements gathered from statisticians, administrators, and investigators from multiple institutions, the authors developed infrastructure and tools to support multisite comparative effectiveness studies using web services for multivariate statistical estimation in the SCANNER federated network. RESULTS: The authors implemented massively parallel (map-reduce) computation methods and a new policy management system to enable each study initiated by network participants to define the ways in which data may be processed, managed, queried, and shared. The authors illustrated the use of these systems among institutions with highly different policies and operating under different state laws. DISCUSSION AND CONCLUSION: Federated research networks need not limit distributed query functionality to count queries, cohort discovery, or independently estimated analytic models. Multivariate analyses can be efficiently and securely conducted without patient-level data transport, allowing institutions with strict local data storage requirements to participate in sophisticated analyses based on federated research networks.

Abstract Many production Grid and e‐Science infrastructures have begun to offer services to end‐users during the past several years with an increasing number of scientific applications that require access to a wide variety of resources and services in multiple Grids. Therefore, the Grid Interoperation Now—Community Group of the Open Grid Forum—organizes and manages interoperation efforts among those production Grid infrastructures to reach the goal of a world‐wide Grid vision on a technical level in the near future. This contribution highlights fundamental approaches of the group and discusses open standards in the context of production e‐Science infrastructures. Copyright © 2009 John Wiley & Sons, Ltd.

In production Grids for scientific applications, service and resource failures must be detected and addressed quickly. In this paper, we describe the monitoring infrastructure used by the Earth System Grid (ESG) project, a scientific collaboration that supports global climate research. ESG uses the Globus Toolkit Monitoring and Discovery System (MDS4) to monitor its resources. We describe how the MDS4 Index Service collects information about ESG resources and how the MDS4 Trigger Service checks specified failure conditions and notifies system administrators when failures occur. We present monitoring statistics for May 2006 and describe our experiences using MDS4 to monitor ESG resources over the last two years.

Grid computing is concerned with the sharing and coordinated use of diverse resources in distributed "virtual organizations." The dynamic and multiinstitutional nature of these environments introduces challenging security issues that demand new technical approaches. In particular, one must deal with diverse local mechanisms, support dynamic creation of services, and enable dynamic creation of trust domains. We describe how these issues are addressed in two generations of the Globus Toolkit/spl reg/. First, we review the Globus Toolkit version 2 (GT2) approach; then we describe new approaches developed to support the Globus Toolkit version 3 (GT3) implementation of the Open Grid Services Architecture, an initiative that is recasting Grid concepts within a service-oriented framework based on Web services. GT3's security implementation uses Web services security mechanisms for credential exchange and other purposes, and introduces a tight least-privilege model that avoids the need for any privileged network service.

Advances in computational, storage and network technologies as well as middle ware such as the Globus Toolkit allow scientists to expand the sophistication and scope of data-intensive applications. These applications produce and analyze terabytes and petabytes of data that are distributed in millions of files or objects. To manage these large data sets efficiently, metadata or descriptive information about the data needs to be managed. There are various types of metadata, and it is likely that a range of metadata services will exist in Grid environments that are specialized for particular types of metadata cataloguing and discovery. In this paper, we present the design of a Metadata Catalog Service (MCS) that provides a mechanism for storing and accessing descriptive metadata and allows users to query for data items based on desired attributes. We describe our experience in using the MCS with several applications and present a scalability study of the service.

Many Physics experiments today generate large volumes of data. That data is then processed in a variety of ways in order to achieve the understanding of fundamental physical phenomena. The goal of the NSF-funded GriPhyN project (Grid Physics Network) is to enable scientists to seamlessly access data whether it is raw experimental data or a data product which is a result of further processing. GriPhyN provides a new degree of transparency in how data-handling and processing capabilities are integrated to deliver data products to end-users or applications, so that requests for such products are easily mapped into computation and/or data access at multiple locations. GriPhyN refers to the set of all data products available to the user as virtual data. Among the physics applications participating in the project is the Laser Interferometer Gravitational-wave Observatory (LIGO), which is being built to observe the gravitational waves predicted by general relativity. We describe our initial design and prototype of a virtual data Grid for LIGO.