Large-scale multiple perturbation experiments have the potential to reveal a more detailed understanding of the molecular pathways that respond to genetic and environmental changes. A key question in these studies is which gene expression changes are important for the response to the perturbation. This problem is challenging because (i) the functional form of the nonlinear relationship between gene expression and the perturbation is unknown and (ii) identification of the most important genes is a high-dimensional variable selection problem. To deal with these challenges, we present here a method based on the model-X knockoffs framework and Deep Neural Networks to identify significant gene expression changes in multiple perturbation experiments. This approach makes no assumptions on the functional form of the dependence between the responses and the perturbations and it enjoys finite sample false discovery rate control for the selected set of important gene expression responses. We apply this approach to the Library of Integrated Network-Based Cellular Signature data sets which is a National Institutes of Health Common Fund program that catalogs how human cells globally respond to chemical, genetic and disease perturbations. We identified important genes whose expression is directly modulated in response to perturbation with anthracycline, vorinostat, trichostatin-a, geldanamycin and sirolimus. We compare the set of important genes that respond to these small molecules to identify co-responsive pathways. Identification of which genes respond to specific perturbation stressors can provide better understanding of the underlying mechanisms of disease and advance the identification of new drug targets.

Multi-user panoramic video streaming demands 4~6× bandwidth of a regular video with the same resolution, which poses a significant challenge on the wireless scheduling design to achieve desired performance. On the other hand, recent studies reveal that one can effectively predict the user's Field-of-View (FoV) and thus simply deliver the corresponding portion instead of the entire scenes. Motivated by this important fact, we aim to employ autoregressive process for motion prediction and analytically characterize the user's successful viewing probability as a function of the delivered portion. Then, we consider the problem of wireless scheduling design with the goal of maximizing application-level throughput (i.e., average rate for successfully viewing the desired content) and service regularity performance (i.e., how often each user gets successful views) subject to the minimum required service rate and wireless interference constraints. As such, we incorporate users' successful viewing probabilities into our scheduling design and develop a scheduling algorithm that not only asymptotically achieves the optimal application-level throughput but also provides service regularity guarantees. Finally, we perform simulations to demonstrate the efficiency of our proposed algorithm using a real dataset of users' head motion.