Multimodal protein language models (PLMs) integrate sequence and token-based structural information, serving as a powerful foundation for protein modeling, generation, and design. However, the reliance on tokenizing 3D structures into discrete tokens causes substantial loss of fidelity about fine-grained structural details and correlations. In this paper, we systematically elucidate the design space of multimodal PLMs to overcome their limitations. We identify tokenization loss and inaccurate structure token predictions by the PLMs as major bottlenecks. To address these, our proposed design space covers improved generative modeling, structure-aware architectures and representation learning, and data exploration. Our advancements approach finer-grained supervision, demonstrating that token-based multimodal PLMs can achieve robust structural modeling. The effective design methods dramatically improve the structure generation diversity, and notably, folding abilities of our 650M model by reducing the RMSD from 5.52 to 2.36 on PDB testset, even outperforming 3B baselines and on par with the specialized folding models. Project page and code: https://bytedance.github.io/dplm/dplm-2.1.

While self-supervised learning has been shown to benefit a number of vision tasks, existing techniques mainly focus on image-level manipulation, which may not generalize well to downstream tasks at patch or pixel levels. Moreover, existing SSL methods might not sufficiently describe and associate the above representations within and across image scales. In this paper, we propose a Self-Supervised Pyramid Representation Learning (SS-PRL) framework. The proposed SS-PRL is designed to derive pyramid representations at patch levels via learning proper prototypes, with additional learners to observe and relate inherent semantic information within an image. In particular, we present a cross-scale patch-level correlation learning in SS-PRL, which allows the model to aggregate and associate information learned across patch scales. We show that, with our proposed SS-PRL for model pre-training, one can easily adapt and fine-tune the models for a variety of applications including multi-label classification, object detection, and instance segmentation.