Delta compression can complement data deduplication by further minimizing redundancy through the compression of non-duplicate data chunks. When adding delta compression to deduplication-based backup systems, however, two primary challenges arise that degrade performance of inline deduplication. First, extra I/Os are introduced along the critical paths of backup and restoration for retrieving base chunks, slowing the system. Second, rewriting techniques prohibit specific data chunks from serving as base chunks for delta compression to improve restore performance, resulting in a loss of compression efficiency. In this paper, we introduce LoopDelta, a framework that seamlessly integrates delta compression into inline deduplication for backup storage, addressing the aforementioned challenges by using three techniques: (1) dual-locality-based similarity tracking leverages both logical and physical locality to detect most of the similar chunks, which, due to their locality, can be prefetched by piggybacking on routine operations during deduplication, thereby eliminating extra I/Os during backup; (2) cache-aware filter identifies base chunks requiring extra I/Os during restore and prevents their referencing, thus eliminating extra restore I/Os; and (3) inversed delta compression, which reverses the roles of base and target chunks in the traditional delta compression approach, thereby allowing for the delta compression of data chunks that are otherwise prohibited as base chunks due to rewriting techniques. Experiments show that LoopDelta increases the compression ratio by 1.28 to 11.33 times over basic deduplication, without significantly affecting backup throughput, and enhances restore performance by up to 3.57 times.

Peptide drugs are becoming star drug agents with high efficiency and selectivity which open up new therapeutic avenues for various diseases. However, the sensitivity to hydrolase and the relatively short half-life have severely hindered their development. In this study, a new generation artificial intelligence-based system for accurate prediction of peptide half-life was proposed, which realized the half-life prediction of both natural and modified peptides and successfully bridged the evaluation possibility between two important species (human, mouse) and two organs (blood, intestine). To achieve this, enzymatic cleavage descriptors were integrated with traditional peptide descriptors to construct a better representation. Then, robust models with accurate performance were established by comparing traditional machine learning and transfer learning, systematically. Results indicated that enzymatic cleavage features could certainly enhance model performance. The deep learning model integrating transfer learning significantly improved predictive accuracy, achieving remarkable R2 values: 0.84 for natural peptides and 0.90 for modified peptides in human blood, 0.984 for natural peptides and 0.93 for modified peptides in mouse blood, and 0.94 for modified peptides in mouse intestine on the test set, respectively. These models not only successfully composed the above-mentioned system but also improved by approximately 15% in terms of correlation compared to related works. This study is expected to provide powerful solutions for peptide half-life evaluation and boost peptide drug development.