Diffusion tensor fields reveal the underlying anatomical structures in biological tissues such as neural fibers in the brain. Most current methods for visualizing the diffusion tensor field can be categorized into two classes: integral curves and glyphs. Integral curves are continuous and represent the underlying fiber structures, but are prone to integration error and loss of local information. Glyphs are useful for representing local tensor information, but do not convey the connectivity in the anatomical structures well. We introduce a simple yet effective visualization technique that extends the streamball method in flow visualization to tensor ellipsoids. Each tensor ellipsoid represents a local tensor, and either blends with neighboring tensors or breaks away from them depending on their orientations and anisotropies. The resulting visualization shows the connectivity information in the underlying anatomy while characterizing the local tenors in detail. By interactively changing an iso-value parameter, users can examine the diffusion tensor field in the entire spectrum between the continuous integral curves and the discrete glyphs. Expert evaluation indicates that this method conveys very useful visual information about local anisotropy in white matter fibers. Such information was previously unavailable in tractography models. Our method provides a visual tool for assessing variability in DTI fiber tract integrity and its relation to function.

Visual exploration is essential to the visualization and analysis of densely sampled 3D DTI fibers in biological specimens, due to the high geometric, spatial, and anatomical complexity of fiber tracts. Previous methods for DTI fiber visualization use zooming, color-mapping, selection, and abstraction to deliver the characteristics of the fibers. However, these schemes mainly focus on the optimization of visualization in the 3D space where cluttering and occlusion make grasping even a few thousand fibers difficult. This paper introduces a novel interaction method that augments the 3D visualization with a 2D representation containing a low-dimensional embedding of the DTI fibers. This embedding preserves the relationship between the fibers and removes the visual clutter that is inherent in 3D renderings of the fibers. This new interface allows the user to manipulate the DTI fibers as both 3D curves and 2D embedded points and easily compare or validate his or her results in both domains. The implementation of the framework is GPU based to achieve real-time interaction. The framework was applied to several tasks, and the results show that our method reduces the user's workload in recognizing 3D DTI fibers and permits quick and accurate DTI fiber selection.

Abstract Diffusion tensor imaging (DTI) has been used to generate fibrous structures in both brain white matter and muscles. Fiber clustering groups the DTI fibers into spatially and anatomically related tracts. As an increasing number of fiber clustering methods have been recently developed, it is important to display, compare, and explore the clustering results efficiently and effectively. In this paper, we present an anatomical visualization technique that reduces the geometric complexity of the fiber tracts and emphasizes the high‐level structures. Beginning with a volumetric diffusion tensor image, we first construct a hierarchical clustering representation of the fiber bundles. These bundles are then reformulated into a 3D multi‐valued volume data. We then build a set of geometric hulls and principal fibers to approximate the shape and orientation of each fiber bundle. By simultaneously visualizing the geometric hulls, individual fibers, and other data sets such as fractional anisotropy, the overall shape of the fiber tracts are highlighted, while preserving the fibrous details. A rater with expert knowledge of white matter structure has evaluated the resulting interactive illustration and confirmed the improvement over straightforward DTI fiber tract visualization.

We present a method for clustering diffusion tensor imaging (DTI) integral curves into anatomically plausible bundles. An expert rater evaluated the anatomical accuracy of the bundles. We also evaluated the method by applying an experimental cross-subject labeling method to the clustering results. We first employ a sampling and culling strategy for generating DTI integral curves and then constrain the curves so that they terminate in gray matter. We then employ a clustering method based on a proximity measure calculated between every pair of curves. We interactively selected a proximity threshold to achieve visually optimal clustering in models from four DTI datasets. An expert rater then assigned a confidence rating about bundle presence and accuracy for each of 12 target fiber bundles of varying calibers and type in each dataset. We then created a fiber bundle template to cluster and label the fiber bundles automatically in new datasets. According to expert evaluation, the automated proximity-based clustering and labeling algorithm consistently yields anatomically plausible fiber bundles on large and coherent clusters. This work has the potential to provide an automatic and robust way to find and study neural fiber bundles within DTI.