Abstract Motivation: Heterogeneity of databases and software resources continues to hamper the integration of biological information. Top-down solutions are not feasible for the full-scale problem of integration across biological species and data types. Bottom-up solutions so far have not integrated, in a maximally flexible way, dynamic and interactive graphical-user-interface components with data repositories and analysis tools. Results: We present a component-based approach that relies on a generalized platform for component integration. The platform enables independently-developed components to synchronize their behavior and exchange services, without direct knowledge of one another. An interface-based data model allows the exchange of information with minimal component interdependency. From these interactions an integrated system results, which we call ISYS\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(^{TM}\) \end{document}. By allowing services to be discovered dynamically based on selected objects, ISYS encourages a kind of exploratory navigation that we believe to be well-suited for applications in genomic research. Availability: A ‘developer’s kit’ for creating software that uses the ISYS platform is available at www.ncgr.org/research/isys/devrel.html. It includes a more refined and fully documented version of the platform and a starting set of ISYS-ready components. Up-to-date descriptions of the ISYS project can be found at www.ncgr.org/research/isys. Contact: [email protected] * To whom correspondence should be addressed.