One-shot pruning efficiently compresses Large Language Models but produces coarse sparse weights, causing significant performance degradation. Traditional fine-tuning approaches to refine these weights are prohibitively expensive for large models. This highlights the need for a training-free weight refinement method that works seamlessly with one-shot pruning and can efficiently recover the lost performance. To tackle this problem, we propose Efficient Iterative Weight Refinement (EIWR), a lightweight, plug-and-play, and training-free method that refines pruned weights through layer-wise iterative optimization. EIWR achieves efficient weight refinement via three key components: a Global Soft Constraint that eliminates costly row-wise Hessian inversions and expands the solution space; a Historical Momentum Strategy that leverages one-shot pruning priors to accelerate convergence and enhance final performance; and Neumann Series Extrapolation that significantly speeds up per-iteration computation. As a result, EIWR enables effective weight refinement with minimal time and memory overhead. Extensive experiments on LLaMA2/3 and Qwen under different pruning strategies and sparsity levels demonstrate that our method can efficiently refine sparse weights and mitigate performance degradation. For example, on LLaMA2-7B under 70 percent sparsity, EIWR reduces perplexity by 15 percent compared with SparseGPT on the WikiText2 benchmark, with only 1.81 additional minutes of computation and 1GB of additional memory.

Xiaoyu Liu, Yun Zhang, Wei Li, Simiao Li, Xudong Huang, Hanting Chen, Yehui Tang, Jie Hu, Zhiwei Xiong, Yunhe Wang. Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2026.

Post-training quantization (PTQ) has played a pivotal role in compressing large language models (LLMs) at ultra-low costs. Although current PTQ methods have achieved promising results by addressing outliers and employing layer- or block-wise loss optimization techniques, they still suffer from significant performance degradation at ultra-low bits precision. To dissect this issue, we conducted an in-depth analysis of quantization errors specific to LLMs and surprisingly discovered that, unlike traditional sources of quantization errors, the growing number of model parameters, combined with the reduction in quantization bits, intensifies inter-layer and intra-layer dependencies, which severely impact quantization accuracy. This finding highlights a critical challenge in quantizing LLMs. To address this, we propose CBQ, a cross-block reconstruction-based PTQ method for LLMs. CBQ leverages a cross-block dependency to establish long-range dependencies across multiple blocks and integrates an adaptive LoRA-Rounding technique to manage intra-layer dependencies. To further enhance performance, CBQ incorporates a coarse-to-fine pre-processing mechanism for processing weights and activations. Extensive experiments show that CBQ achieves superior low-bit quantization (W4A4, W4A8, W2A16) and outperforms existing state-of-the-art methods across various LLMs and datasets. Notably, CBQ only takes 4.3 hours to quantize a weight-only quantization of a 4-bit LLAMA1-65B model, achieving a commendable trade off between performance and efficiency.

Recent works have correlated Masked Image Modeling (MIM) with consistency regularization in Unsupervised Domain Adaptation (UDA). However, they merely treat masking as a special form of deformation on the input images and neglect the theoretical analysis, which leads to a superficial understanding of masked reconstruction and insufficient exploitation of its potential in enhancing feature extraction and representation learning. In this paper, we reframe masked reconstruction as a sparse signal reconstruction problem and theoretically prove that the dual form of complementary masks possesses superior capabilities in extracting domain-agnostic image features. Based on this compelling insight, we propose MaskTwins, a simple yet effective UDA framework that integrates masked reconstruction directly into the main training pipeline. MaskTwins uncovers intrinsic structural patterns that persist across disparate domains by enforcing consistency between predictions of images masked in complementary ways, enabling domain generalization in an end-to-end manner. Extensive experiments verify the superiority of MaskTwins over baseline methods in natural and biological image segmentation. These results demonstrate the significant advantages of MaskTwins in extracting domain-invariant features without the need for separate pre-training, offering a new paradigm for domain-adaptive segmentation. The source code is available at https://github.com/jwwang0421/masktwins.

Proposal-free instance segmentation methods have significantly advanced the field of biological image analysis. Recently, the Segment Anything Model (SAM) has shown an extraordinary ability to handle challenging instance boundaries. However, directly applying SAM to biological images that contain instances with complex morphologies and dense distributions fails to yield satisfactory results. In this work, we propose BioSAM, a new biological instance segmentation framework generating SAM prompts from a superpixel graph. Specifically, to avoid over-merging, we first generate sufficient superpixels as graph nodes and construct an initialized graph. We then generate initial prompts from each superpixel and aggregate them through a graph neural network (GNN) by predicting the relationship of superpixels to avoid over-segmentation. We employ the SAM encoder embeddings and the SAM-assisted superpixel similarity as new features for the graph to enhance its discrimination capability. With the graph-based prompt aggregation, we utilize the aggregated prompts in SAM to refine the segmentation and generate more accurate instance boundaries. Comprehensive experiments on four representative biological datasets demonstrate that our proposed method outperforms state-of-the-art methods.

Accurate 3D neuron segmentation from electron mi-croscopy (EM) volumes is crucial for neuroscience re-search. However, the complex neuron morphology often leads to over-merge and over-segmentation results. Recent advancements utilize 3D CNNs to predict a 3D affinity map with improved accuracy but suffer from two challenges: high computational cost and limited input size, especially for practical deployment for large-scale EM volumes. To address these challenges, we propose a novel method to leverage lightweight 2D CNNs for efficient neuron segmen-tation. Our method employs a 2D Y-shape network to generate two embedding maps from adjacent 2D sections, which are then converted into an affinity map by measuring their embedding distance. While the 2D network better captures pixel dependencies inside sections with larger in-put sizes, it overlooks inter-section dependencies. To over-come this, we introduce a cross-dimension affinity distillation (CAD) strategy that transfers inter-section dependency knowledge from a 3D teacher network to the 2D student network by ensuring consistency between their output affin-ity maps. Additionally, we design a feature grafting in-teraction (FGI) module to enhance knowledge transfer by grafting embedding maps from the 2D student onto those from the 3D teacher. Extensive experiments on multiple EM neuron segmentation datasets, including a newly built one by ourselves, demonstrate that our method achieves supe-rior performance over state-of-the-art methods with only 1/20 inference latency. We release our code and dataset at https://github.com/liuxyll03/CAD.

In image restoration (IR), leveraging semantic priors from segmentation models has been a common approach to improve performance. The recent segment anything model (SAM) has emerged as a powerful tool for extracting advanced semantic priors to enhance IR tasks. However, the computational cost of SAM is prohibitive for IR, compared to existing smaller IR models. The incorporation of SAMfor extracting semantic priors considerably hampers the model inference efficiency. To address this issue, we propose a general framework to distill SAM's semantic knowledge to boost exiting IR models without interfering with their inference process. Specifically, our proposed framework consists of the semantic priors fusion (SPF) scheme and the semantic priors distillation (SPD) scheme. SPF fuses two kinds of information between the restored image predicted by the original IR model and the semantic mask predicted by SAM for the refined restored image. SPD leverages a self-distillation manner to distill the fused semantic priors to boost the performance of original IR models. Additionally, we design a semantic-guided relation (SGR) module for SPD, which ensures semantic feature representation space consistency to fully distill the priors. We demonstrate the effectiveness of our framework across multiple IR models and tasks, including deraining, deblurring, and denoising.

Electron microscopy (EM) images are notoriously challenging to segment due to their complex structures and lack of effective annotations. Fortunately, large-scale self-supervised pretraining offers a promising solution by allowing us to acquire prior knowledge of cell and subcellular tissue structures, which can significantly improve EM instance segmentation results. However, most existing pretraining methods fail to capture the crucial local information that is essential for EM images, instead focusing only on high-level semantic information. In this paper, we propose a novel pretraining framework that leverages multiscale visual representations to adapt to the complex structures of EM images. Our framework achieves instance-level alignment by maximizing the consistency between strongly and weakly augmented images, while also incorporating a cross-attention mechanism to match multiscale features and encode more low-level information into high-level semantics. Most importantly, our approach employs multi-task optimization on the feature pyramid, enabling multiscale pixel restoration and feature comparison. We extensively pretrain our method on four large-scale EM datasets and demonstrate significant gains on neuron and mitochondria segmentation tasks. Code is available at https://github.com/ydchen0806/MS-Con-EM-Seg.

Significant progress has been made in self-supervised image denoising (SSID) in the recent few years. However, most methods focus on dealing with spatially independent noise, and they have little practicality on real-world sRGB images with spatially correlated noise. Although pixel-shuffle downsampling has been suggested for breaking the noise correlation, it breaks the original information of images, which limits the denoising performance. In this paper, we propose a novel perspective to solve this problem, i.e., seeking for spatially adaptive supervision for real-world sRGB image denoising. Specifically, we take into account the respective characteristics of flat and textured regions in noisy images, and construct supervisions for them separately. For flat areas, the supervision can be safely derived from non-adjacent pixels, which are much far from the current pixel for excluding the influence of the noise-correlated ones. And we extend the blind-spot network to a blind-neighborhood network (BNN) for providing supervision on flat areas. For textured regions, the supervision has to be closely related to the content of adjacent pixels. And we present a locally aware network (LAN) to meet the requirement, while LAN itself is selectively supervised with the output of BNN. Combining these two supervisions, a denoising network (e.g., U-Net) can be well-trained. Extensive experiments show that our method performs favorably against state-of-the-art SSID methods on real-world sRGB photographs. The code is available at https://github.com/nagejacob/SpatiallyAdaptiveSSID.

Neuron reconstruction in a full adult fly brain from high-resolution electron microscopy (EM) data is regarded as a cornerstone for neuroscientists to explore how neurons inspire intelligence. As the central part of neurons, somas in the full brain indicate the origin of neurogenesis and neural functions. However, due to the absence of EM datasets specifically annotated for somas, existing deep learning-based neuron reconstruction methods cannot directly provide accurate soma distribution and morphology. Moreover, full brain neuron reconstruction remains extremely time-consuming due to the unprecedentedly large size of EM data. In this paper, we develop an efficient soma reconstruction method for obtaining accurate soma distribution and morphology information in a full adult fly brain. To this end, we first make a high-resolution EM dataset with fine-grained 3D manual annotations on somas. Relying on this dataset, we propose an efficient, two-stage deep learning algorithm for predicting accurate locations and boundaries of 3D soma instances. Further, we deploy a parallelized, high-throughput data processing pipeline for executing the above algorithm on the full brain. Finally, we provide quantitative and qualitative benchmark comparisons on the testset to validate the superiority of the proposed method, as well as preliminary statistics of the reconstructed somas in the full adult fly brain from the biological perspective. We release our code and dataset at https://github.com/liuxy1103/EMADS.

Sparse instance-level supervision has recently been explored to address insufficient annotation in biomedical instance segmentation, which is easier to annotate crowded instances and better preserves instance completeness for 3D volumetric datasets compared to common semi-supervision. In this paper, we propose a sparsely supervised biomedical instance segmentation framework via cross-representation affinity consistency regularization. Specifically, we adopt two individual networks to enforce the perturbation consistency between an explicit affinity map and an implicit affinity map to capture both feature-level instance discrimination and pixel-level instance boundary structure. We then select the highly confident region of each affinity map as the pseudo label to supervise the other one for affinity consistency learning. To obtain the highly confident region, we propose a pseudo-label noise filtering scheme by integrating two entropy-based decision strategies. Extensive experiments on four biomedical datasets with sparse instance annotations show the state-of-the-art performance of our proposed framework. For the first time, we demonstrate the superiority of sparse instance-level supervision on 3D volumetric datasets, compared to common semi-supervision under the same annotation cost. Code is available at https://github.com/liuxy1103/CRAC.

For improving image composition and aesthetic quality, most existing methods modulate the captured images by striking out redundant content near the image borders. However, such image cropping methods are limited in the range of image views. Some methods have been suggested to extrapolate the images and predict cropping boxes from the extrapolated image. Nonetheless, the synthesized extrapolated regions may be included in the cropped image, making the image composition result not real and potentially with degraded image quality. In this paper, we circumvent this issue by presenting a joint framework for both unbounded recommendation of camera view and image composition (i.e., UNIC). In this way, the cropped image is a sub-image of the image acquired by the predicted camera view, and thus can be guaranteed to be real and consistent in image quality. Specifically, our framework takes the current camera preview frame as input and provides a recommendation for view adjustment, which contains operations unlimited by the image borders, such as zooming in or out and camera movement. To improve the prediction accuracy of view adjustment prediction, we further extend the field of view by feature extrapolation. After one or several times of view adjustments, our method converges and results in both a camera view and a bounding box showing the image composition recommendation. Extensive experiments are conducted on the datasets constructed upon existing image cropping datasets, showing the effectiveness of our UNIC in unbounded recommendation of camera view and image composition. The source code, dataset, and pre-trained models is available at https://github.com/liuxiaoyu1104/UNIC.

Recent advanced proposal-free instance segmentation methods have made significant progress in biological images. However, existing methods are vulnerable to local imaging artifacts and similar object appearances, resulting in over-merge and over-segmentation. To reduce these two kinds of errors, we propose a new biological instance segmentation framework based on a superpixel-guided graph, which consists of two stages, i.e., superpixel-guided graph construction and superpixel agglomeration. Specifically, the first stage generates enough superpixels as graph nodes to avoid over-merge, and extracts node and edge features to construct an initialized graph. The second stage agglomerates superpixels into instances based on the relationship of graph nodes predicted by a graph neural network (GNN). To solve over-segmentation and prevent introducing additional over-merge, we specially design two loss functions to supervise the GNN, i.e., a repulsion-attraction (RA) loss to better distinguish the relationship of nodes in the feature space, and a maximin agglomeration score (MAS) loss to pay more attention to crucial edge classification. Extensive experiments on three representative biological datasets demonstrate the superiority of our method over existing state-of-the-art methods. Code is available at https://github.com/liuxy1103/BISSG.