Genome sequence analysis is fundamental to medical breakthroughs such as developing vaccines, enabling genome editing, and facilitating personalized medicine. The exponentially expanding sequencing datasets and complexity of sequencing algorithms necessitate performance enhancements. While the performance of software solutions is constrained by their underlying hardware platforms, the utility of fixed-function accelerators is restricted to only certain sequencing algorithms.This paper presents QUETZAL, the first general-purpose vector acceleration framework designed for high efficiency and broad applicability across a diverse set of genomics algorithms. While a commercial CPU’s vector datapath is a promising candidate to exploit the data-level parallelism in genomics algorithms, our analysis finds that its performance is often limited due to long-latency scatter/gather memory instructions. QUETZAL introduces a hardware-software co-design comprising an accelerator microarchitecture closely integrated with the CPU’s vector datapath, alongside novel vector instructions to fully capitalize on the proposed hardware. QUETZAL integrates a set of scratchpad-style buffers meticulously designed to minimize latency associated with scatter/gather instructions during the retrieval of input genome sequences data. QUETZAL supports both short and long reads, and different types of sequencing data formats. A combination of hardware and software techniques enables QUETZAL to reduce the latency of memory instructions, perform complex computation using a single instruction, and transform data representations at runtime, resulting in overall efficiency gain. QUETZAL significantly accelerates a vectorized CPU baseline on modern genome sequence analysis algorithms by 5.7×, while incurring a small area overhead of 1.4% post place-and-route at the 7nm technology node compared to an HPC ARM CPU.

Database Management Systems (DBMS) have be-come an essential tool for industry and research and are often a significant component of data centers. There have been many efforts to accelerate DBMS application performance. One of the most explored techniques is the use of vector processing. Unfortunately, conventional vector architectures have not been able to exploit the full potential of DBMS acceleration.In this paper, we present VAQUERO, our Scratchpad-based Vector Accelerator for QUEry pROcessing. VAQUERO improves the efficiency of vector architectures for DBMS operations such as data aggregation and hash joins featuring lookup tables. Lookup tables are significant contributors to the performance bottlenecks in DBMS processing suffering from insufficient ISA support in the form of scatter-gather instructions. VAQUERO introduces a novel Advanced Scratchpad Memory specifically designed with two mapping modes — direct- and associative-mode. These map-ping modes enable VAQUERO to accelerate real-world databases with workload sizes that significantly exceed the scratchpad memory capacity. Additionally, the associative-mode allows to use VAQUERO with DBMS operators that use hashed keys, e.g. hash-join and hash-aggregate. VAQUERO has been designed considering general DBMS algorithm requirements instead of being based on a particular database organization. For this reason, VAQUERO is capable to accelerate DBMS operators for both row- and column-oriented databases.In this paper, we evaluate the efficiency of VAQUERO using two highly optimized popular open-source DBMS, namely the row-based PostgreSQL and column-based MonetDB. We imple-mented VAQUERO at the RTL level and prototype it, by performing Place&Route, at the 7nm technology node. VAQUERO incurs a modest 0.15% area overhead compared with an Intel Ice Lake processor. Our evaluation shows that VAQUERO significantly outperforms PostgreSQL and MonetDB by 2.09× and 3.32× respectively, when processing operators and queries from the TPC-H benchmark.

The ever-increasing yields in genome sequence data production pose a computational challenge to current genome sequence analysis tools, jeopardizing the future of personalized medicine. Leveraging hardware accelerators (GPUs, FPGAs, and ASICs) to accelerate computationally-intensive algorithms like sequence alignment has become paramount. Recently, the wavefront alignment algorithm was introduced, significantly reducing the execution time to perform sequence alignment. This paper presents the first-ever ASIC accelerator of the WFA integrated into a RISC-V system-on-chip. Our designed chip greatly accelerates sequence alignment, delivering up to 1076 × better performance over the CPU implementation of the WFA running on the RISC-V core of the chip.

The maturity level of RISC-V and the availability of domain-specific instruction set extensions, like vector processing, make RISC-V a good candidate for supporting the integration of specialized hardware in processor cores for the High Performance Computing (HPC) application domain. In this article, 1 we present Vitruvius+, the vector processing acceleration engine that represents the core of vector instruction execution in the HPC challenge that comes within the EuroHPC initiative. It implements the RISC-V vector extension (RVV) 0.7.1 and can be easily connected to a scalar core using the Open Vector Interface standard. Vitruvius+ natively supports long vectors: 256 double precision floating-point elements in a single vector register. It is composed of a set of identical vector pipelines (lanes), each containing a slice of the Vector Register File and functional units (one integer, one floating point). The vector instruction execution scheme is hybrid in-order/out-of-order and is supported by register renaming and arithmetic/memory instruction decoupling. On a stand-alone synthesis, Vitruvius+ reaches a maximum frequency of 1.4 GHz in typical conditions (TT/0.80V/25°C) using GlobalFoundries 22FDX FD-SOI. The silicon implementation has a total area of 1.3 mm 2 and maximum estimated power of ∼920 mW for one instance of Vitruvius+ equipped with eight vector lanes.

Linear algebra computational kernels based on byte and sub-byte integer data formats are at the base of many classes of applications, ranging from Deep Learning to Pattern Matching. Porting the computation of these applications from cloud to edge and mobile devices would enable significant improvements in terms of security, safety, and energy efficiency. However, despite their low memory and energy demands, their intrinsically high computational intensity makes the execution of these workloads challenging on highly resource-constrained devices. In this paper, we present BiSon-e, a novel RISC-V based architecture that accelerates linear algebra kernels based on narrow integer computations on edge processors by performing Single Instruction Multiple Data (SIMD) operations on off-the-shelf scalar Functional Units (FUs). Our novel architecture is built upon the binary segmentation technique, which allows to significantly reduce the memory footprint and the arithmetic intensity of linear algebra kernels requiring narrow data sizes. We integrate BiSon-e into a complete System-on-Chip (SoC) based on RISC-V, synthesized and Place&Routed in 65nm and 22nm technologies, introducing a negligible 0.07% area overhead with respect to the baseline architecture. Our experimental evaluation shows that, when computing the Convolution and Fully-Connected layers of the AlexNet and VGG-16 Convolutional Neural Networks (CNNs) with 8-, 4-, and 2-bit, our solution gains up to 5.6×, 13.9× and 24× in execution time compared to the scalar implementation of a single RISC-V core, and improves the energy efficiency of string matching tasks by 5× when compared to a RISC-V-based Vector Processing Unit (VPU).

Contemporary Vector Processors (VPs) are de-signed either for short vector lengths, e.g., Fujitsu A64FX with 512-bit ARM SVE vector support, or long vectors, e.g., NEC Aurora Tsubasa with 16Kbits Maximum Vector Length (MVL1). Unfortunately, both approaches have drawbacks. On the one hand, short vector length VP designs struggle to provide high efficiency for applications featuring long vectors with high Data Level Parallelism (DLP). On the other hand, long vector VP designs waste resources and underutilize the Vector Register File (VRF) when executing low DLP applications with short vector lengths. Therefore, those long vector VP implementations are limited to a specialized subset of applications, where relatively high DLP must be present to achieve excellent performance with high efficiency. Modern scientific applications are getting more diverse, and the vector lengths in those applications vary widely. To overcome these limitations, we propose an Adaptable Vector Architecture (AVA) that leads to having the best of both worlds. AVA is designed for short vectors (MVL=16 elements) and is thus area and energy-efficient. However, AVA has the functionality to reconfigure the MVL, thereby allowing to exploit the benefits of having a longer vector of up to 128 elements microarchitecture when abundant DLP is present. We model AVA on the gem5 simulator and evaluate AVA performance with six applications taken from the RiVEC Benchmark Suite. To obtain area and power consumption metrics, we model AVA on McPAT for 22nm technology. Our results show that by reconfiguring our small VRF (8KB) plus our novel issue queue scheme, AVA yields a 2X speedup over the default configuration for short vectors. Additionally, AVA shows competitive performance when compared to a long vector VP, while saving 50% of area.

This paper presents a 128 × 128-pix high-speed PbSe-CMOS uncooled MWIR imager with pixel digital output. The proposed in-pixel A/D converter based on integrate-and-fire modulation achieves good linearity even at 20 Meps thanks to its soft-reset mechanism. Class-AB CMOS circuits are proposed to keep static power consumption below 10 μW/pix. Each DPS cell also includes its own analog reference and bias generator. The resulting pixel digital-only I/O interface ensures low crosstalk at the FPA level. From post-layout simulation results, the imager is capable of delivering 14 bit up to 1 kfps or alternatively 4 kfps up to 10 bit. The presented MWIR imager is currently being integrated in the 0.18-μm 1P6M CMOS technology from X-FAB.

This paper presents a complete family of integrate- and-fire modulator (IAF) topologies to improve in-pixel signal linearity in digital imagers. Three types of soft-reset schemes are analyzed for capacitive trans-impedance amplifiers (CTIAs). The proposed Type III has the main advantages of avoiding any low-impedance voltage source or extra capacitor, of including correlated double sampling (CDS) for the cancellation of CTIA low-frequency noise, and of minimum current biasing requirements. Comparative electrical simulations are also presented to demonstrate the linearity improvements of soft-reset schemes and the increase of IAF modulation robustness under low-power circuit operation.