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André Flöter

dblp:85/2602 · DBLP profile ↗
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1ranked-venue papers
1as first author
0since 2021 · last 2004
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › metabolomics
metabolite quantification
0.012004
Threshold extraction in metabolite concentration data · Bioinform. 2004
Bioinformatics and computational biology
metabolomics
0.012004
Threshold extraction in metabolite concentration data · Bioinform. 2004

Methods — techniques the papers use, named apart from their topics

discretization · 0.0decision forest · 0.0
YearPublicationVenuePosition
2004 Threshold extraction in metabolite concentration data
abstract
MOTIVATION: Continued development of analytical techniques based on gas chromatography and mass spectrometry now facilitates the generation of larger sets of metabolite concentration data. An important step towards the understanding of metabolite dynamics is the recognition of stable states where metabolite concentrations exhibit a simple behaviour. Such states can be characterized through the identification of significant thresholds in the concentrations. But general techniques for finding discretization thresholds in continuous data prove to be practically insufficient for detecting states due to the weak conditional dependences in concentration data. RESULTS: We introduce a method of recognizing states in the framework of decision tree induction. It is based upon a global analysis of decision forests where stability and quality are evaluated. It leads to the detection of thresholds that are both comprehensible and robust. Applied to metabolite concentration data, this method has led to the discovery of hidden states in the corresponding variables. Some of these reflect known properties of the biological experiments, and others point to putative new states. AVAILABILITY: An implementation of this approach can be obtained from the authors upon request.
André Flöter, Jacques Nicolas, Torsten Schaub, Joachim Selbig
Bioinform.1