With the increasing number of transistors available on a single chip, the system-on-chip (SoC) paradigm has evolved to exploit its full potential. As many processors can be accommodated on a single chip, this paradigm has forced a communication-centric, as opposed to a computation-centric, design view. Thus, the choice, management and modeling of the SoC interconnect is essential for an accurate evaluation and optimization of the global performance of a system. Recently, the notion of network-on-chip (NoC) has been introduced as a way to extend the classical bus-based interconnection, which is still the dominant interconnect structure for SoCs, into a dedicated, segmented and, possibly, packet-switched network fabric (Benini et al., 2002). In this paper, we present a NoC model which, together with a multiprocessor real-time operating system (RTOS) model, allows us to model and analyze the behavior of a complex system that has a real-time application running on a multiprocessor platform. We demonstrate the potential of our model by simulating and analyzing a small multiprocessor system connected through different NoC topologies, and discuss how the simulation model may be used during the design-space exploration phase.