Abstract Summary: Modelling and simulation of complex cellular transactions involve development of platforms that understand diverse mathematical representations and are capable of handling large backend computations. Grid Cellware, an integrated modelling and simulation tool, has been developed to precisely address these niche requirements of the modelling community. Grid Cellware implements various pathway simulation algorithms along with adaptive Swarm algorithm for parameter estimation. For enchanced computational productivity Grid Cellware uses grid technology with Globus as the middleware. Availability: https://www.bii-sg.org/sbg/cellware Contact: [email protected] Supplementary information: User Manual is available as PDF file. Examples are attached to expedite mastering of the software.