The complexes of long non-coding RNAs bound to proteins can be involved in regulating life activities at various stages of organisms. However, in the face of the growing number of lncRNAs and proteins, verifying LncRNA-Protein Interactions (LPI) based on traditional biological experiments is time-consuming and laborious. Therefore, with the improvement of computing power, predicting LPI has met new development opportunity. In virtue of the state-of-the-art works, a framework called LncRNA-Protein Interactions based on Kernel Combinations and Graph Convolutional Networks (LPI-KCGCN) has been proposed in this article. We first construct kernel matrices by taking advantage of extracting both the lncRNAs and protein concerning the sequence features, sequence similarity features, expression features, and gene ontology. Then reconstruct the existent kernel matrices as the input of the next step. Combined with known LPI interactions, the reconstructed similarity matrices, which can be used as features of the topology map of the LPI network, are exploited in extracting potential representations in the lncRNA and protein space using a two-layer Graph Convolutional Network. The predicted matrix can be finally obtained by training the network to produce scoring matrices w.r.t. lncRNAs and proteins. Different LPI-KCGCN variants are ensemble to derive the final prediction results and testify on balanced and unbalanced datasets. The 5-fold cross-validation shows that the optimal feature information combination on a dataset with 15.5% positive samples has an AUC value of 0.9714 and an AUPR value of 0.9216. On another highly unbalanced dataset with only 5% positive samples, LPI-KCGCN also has outperformed the state-of-the-art works, which achieved an AUC value of 0.9907 and an AUPR value of 0.9267.

Drawing support from an effective Medical Image Segmentation (MIS) is conducive to a substantial diagnostic basis for the physicians to identify the focus lesion in the patient body and give the subsequent clinical assessment of the patient status. Although various works have tried the challenging quantitative analysis problem, it is still difficult to conduct precise automatic segmentation, especially the soft tissue organs. In this decade, with the increased amount of available datasets, deep learning-based networks have achieved remarkable performance in image processing. Inspired by the state-of-the-art deep learning works, in this paper, we propose an end-to-end multi-layer network named RCGA-Net. It consists of an encoder-decoder backbone that integrates a coordinate attention mechanism based on space and channel and a global context extraction module to highlight more valuable information. To evaluate the performance of RCGA-Net, we apply it to different kinds of clinical and experimental MIS tasks to testify its generalization ability. Extensive experiments represent that our schema has taken the outperform or compatible results among the comparison methods group. Specifically, the numeric result of RCGA-Net on the pulmonary dataset has achieved a 99.12% optimum F1-score.

BACKGROUND: Protein subcellular localization prediction plays an important role in biology research. Since traditional methods are laborious and time-consuming, many machine learning-based prediction methods have been proposed. However, most of the proposed methods ignore the evolution information of proteins. In order to improve the prediction accuracy, we present a deep learning-based method to predict protein subcellular locations. RESULTS: Our method utilizes not only amino acid compositions sequence but also evolution matrices of proteins. Our method uses a bidirectional long short-term memory network that processes the entire protein sequence and a convolutional neural network that extracts features from protein sequences. The position specific scoring matrix is used as a supplement to protein sequences. Our method was trained and tested on two benchmark datasets. The experiment results show that our method yields accurate results on the two datasets with an average precision of 0.7901, ranking loss of 0.0758 and coverage of 1.2848. CONCLUSION: The experiment results show that our method outperforms five methods currently available. According to those experiments, we can see that our method is an acceptable alternative to predict protein subcellular location.

In this paper, we consider the design of joint resource blocks (RBs) and power allocation for dual-mode base stations operating over millimeter wave (mmW) band and microwave (μW) band. The resource allocation design aims to minimize the system energy consumption while taking into account the channel state information, maximum delay, load, and different types of user applications (UAs). To facilitate the design, we first propose a group-based algorithm to assign UAs to multiple groups. Within each group, low-power UAs, which often appear in short distance and experience less obstacles, are inclined to be served over mmW band. The allocation problem over mmW band can be solved by a greedy algorithm. Over μW band, we propose an estimation-optimal-descent algorithm. The rate of each UA at all RBs is estimated to initialize the allocation. Then, we keep altering RB's ownership until any altering makes power increases. Simulation results show that our proposed algorithm offers an excellent tradeoff between low energy consumption and fair transmission.

MOTIVATION: Accurate identification of N4-methylcytosine (4mC) modifications in a genome wide can provide insights into their biological functions and mechanisms. Machine learning recently have become effective approaches for computational identification of 4mC sites in genome. Unfortunately, existing methods cannot achieve satisfactory performance, owing to the lack of effective DNA feature representations that are capable to capture the characteristics of 4mC modifications. RESULTS: In this work, we developed a new predictor named 4mcPred-IFL, aiming to identify 4mC sites. To represent and capture discriminative features, we proposed an iterative feature representation algorithm that enables to learn informative features from several sequential models in a supervised iterative mode. Our analysis results showed that the feature representations learnt by our algorithm can capture the discriminative distribution characteristics between 4mC sites and non-4mC sites, enlarging the decision margin between the positives and negatives in feature space. Additionally, by evaluating and comparing our predictor with the state-of-the-art predictors on benchmark datasets, we demonstrate that our predictor can identify 4mC sites more accurately. AVAILABILITY AND IMPLEMENTATION: The user-friendly webserver that implements the proposed 4mcPred-IFL is well established, and is freely accessible at http://server.malab.cn/4mcPred-IFL. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Under the big background of the electrical system reform, the importance of financial informationization construction of electrical power business is more and more outstanding. First of all, in this paper the problems of financial informationization were analyzed; Secondly we have discussed the basic principles and actions which taken in different stages of financial informationization planning; finally, an instance of China Southern power Grid is showed.