The Bayesian Cramér-Rao bound (CRB) provides a lower bound on the mean square error of any Bayesian estimator under mild regularity conditions. It can be used to benchmark the performance of statistical estimators, and provides a principled metric for system design and optimization. However, the Bayesian CRB depends on the underlying prior distribution, which is often unknown for many problems of interest. This work introduces a new data-driven estimator for the Bayesian CRB using score matching, i.e., a statistical estimation technique that models the gradient of a probability distribution from a given set of training data. The performance of the proposed estimator is analyzed in both the classical parametric modeling regime and the neural network modeling regime. In both settings, we develop novel non-asymptotic bounds on the score matching error and our Bayesian CRB estimator based on the results from empirical process theory, including classical bounds and recently introduced techniques for characterizing neural networks. We illustrate the performance of the proposed estimator with two application examples: a signal denoising problem and a dynamic phase offset estimation problem with applications in communication systems.

Deep learning has shown astonishing performance in accelerated magnetic resonance imaging (MRI). Most state-of-the-art deep learning reconstructions adopt the powerful convolutional neural network and perform 2D convolution since many magnetic resonance images or their corresponding k-space are in 2D. In this work, we present a new approach that explores the 1D convolution, making the deep network much easier to be trained and generalized. We further integrate the 1D convolution into the proposed deep network, named as One-dimensional Deep Low-rank and Sparse network (ODLS), which unrolls the iteration procedure of a low-rank and sparse reconstruction model. Extensive results on in vivo knee and brain datasets demonstrate that, the proposed ODLS is very suitable for the case of limited training subjects and provides improved reconstruction performance than state-of-the-art methods both visually and quantitatively. Additionally, ODLS also shows nice robustness to different undersampling scenarios and some mismatches between the training and test data. In summary, our work demonstrates that the 1D deep learning scheme is memory-efficient and robust in fast MRI.

Magnetic resonance imaging serves as an essential tool for clinical diagnosis, however, suffers from a long acquisition time. Sparse sampling effectively saves this time but images need to be faithfully reconstructed from undersampled data. Among the existing reconstruction methods, the structured low-rank methods have advantages in robustness to the sampling patterns and lower error. However, the structured low-rank methods use the 2D or higher dimension k-space data to build a huge block Hankel matrix, leading to considerable time and memory consumption. To reduce the size of the Hankel matrix, we proposed to separably construct multiple small Hankel matrices from rows and columns of the k-space and then constrain the low-rankness on these small matrices. This separable model can significantly reduce the computational time but ignores the correlation existed in inter- and intra-row or column, resulting in increased reconstruction error. To improve the reconstructed image without obviously increasing the computation, we further introduced the self-consistency of k-space and virtual coil prior. Besides, the proposed separable model can be extended into other imaging scenarios which hold exponential characteristics in the parameter dimension. The in vivo experimental results demonstrated that the proposed method permits the lowest reconstruction error with a fast reconstruction. The proposed approach requires only 4% of the state-of-the-art STDLR-SPIRiT runtime for parallel imaging reconstruction, and achieves the fastest computational speed in parameter imaging reconstruction.

Magnetic resonance (MR) fingerprinting is a new quantitative imaging paradigm, which simultaneously acquires multiple MR tissue parameter maps in a single experiment. In this paper, we present an estimation-theoretic framework to perform experiment design for MR fingerprinting. Specifically, we describe a discrete-time dynamic system to model spin dynamics, and derive an estimation-theoretic bound, i.e., the Cramér-Rao bound, to characterize the signal-to-noise ratio (SNR) efficiency of an MR fingerprinting experiment. We then formulate an optimal experiment design problem, which determines a sequence of acquisition parameters to encode MR tissue parameters with the maximal SNR efficiency, while respecting the physical constraints and other constraints from the image decoding/reconstruction process. We evaluate the performance of the proposed approach with numerical simulations, phantom experiments, and in vivo experiments. We demonstrate that the optimized experiments substantially reduce data acquisition time and/or improve parameter estimation. For example, the optimized experiments achieve about a factor of two improvement in the accuracy of T2maps, while keeping similar or slightly better accuracy of T1maps. Finally, as a remarkable observation, we find that the sequence of optimized acquisition parameters appears to be highly structured rather than randomly/pseudo-randomly varying as is prescribed in the conventional MR fingerprinting experiments.

This paper introduces a statistical estimation framework for magnetic resonance (MR) fingerprinting, a recently proposed quantitative imaging paradigm. Within this framework, we present a maximum likelihood (ML) formalism to estimate multiple MR tissue parameter maps directly from highly undersampled, noisy k-space data. A novel algorithm, based on variable splitting, the alternating direction method of multipliers, and the variable projection method, is developed to solve the resulting optimization problem. Representative results from both simulations and in vivo experiments demonstrate that the proposed approach yields significantly improved accuracy in parameter estimation, compared to the conventional MR fingerprinting reconstruction. Moreover, the proposed framework provides new theoretical insights into the conventional approach. We show analytically that the conventional approach is an approximation to the ML reconstruction; more precisely, it is exactly equivalent to the first iteration of the proposed algorithm for the ML reconstruction, provided that a gridding reconstruction is used as an initialization.

Magnetic resonance parameter mapping (e.g., T1 mapping, T2 mapping, T*2 mapping) is a valuable tool for tissue characterization. However, its practical utility has been limited due to long data acquisition time. This paper addresses this problem with a new model-based parameter mapping method. The proposed method utilizes a formulation that integrates the explicit signal model with sparsity constraints on the model parameters, enabling direct estimation of the parameters of interest from highly undersampled, noisy k-space data. An efficient greedy-pursuit algorithm is described to solve the resulting constrained parameter estimation problem. Estimation-theoretic bounds are also derived to analyze the benefits of incorporating sparsity constraints and benchmark the performance of the proposed method. The theoretical properties and empirical performance of the proposed method are illustrated in a T2 mapping application example using computer simulations.

Partial separability (PS) and sparsity have been previously used to enable reconstruction of dynamic images from undersampled (k,t)-space data. This paper presents a new method to use PS and sparsity constraints jointly for enhanced performance in this context. The proposed method combines the complementary advantages of PS and sparsity constraints using a unified formulation, achieving significantly better reconstruction performance than using either of these constraints individually. A globally convergent computational algorithm is described to efficiently solve the underlying optimization problem. Reconstruction results from simulated and in vivo cardiac MRI data are also shown to illustrate the performance of the proposed method.