We consider binary integer programming problems with the min-max regret objective function under interval objective coefficients. We propose a heuristic framework, the iterated dual substitution (iDS) algorithm, which iteratively invokes a dual substitution heuristic and excludes from the search space any solution already checked in previous iterations. In iDS, we use a best scenario–based lemma to improve performance. We apply iDS to four typical combinatorial optimization problems: the knapsack problem, the multidimensional knapsack problem, the generalized assignment problem, and the set covering problem. For the multidimensional knapsack problem, we compare the iDS approach with two algorithms widely used for problems with the min-max regret criterion: a fixed-scenario approach, and a branch-and-cut approach. The results of computational experiments on a broad set of benchmark instances show that the proposed iDS approach performs best on most tested instances. For the knapsack problem, the generalized assignment problem, and the set covering problem, we compare iDS with state-of-the-art results. The iDS algorithm successfully updates best-known records for a number of benchmark instances. Summary of Contribution: This paper proposes a heuristic framework for binary integer programming (BIP) problems with the min-max regret objective function under interval objective coefficients. We selected four representative NP-hard combinatorial optimization problems: the knapsack problem, the multidimensional knapsack problem, the set covering problem, and the generalized assignment problem. We show the effectiveness and efficiency of the approach by comparing with state-of-the-art results.