Few-shot medical image segmentation (FSMIS) has attracted increasing attention as a promising technique for solving medical image segmentation tasks by relying on only a small amount of labeled data from new classes. Current FSMIS methods typically employ pixel-level semantic correlations between support-query image pairs to guide the segmentation of query images. However, the class information gap between support and query images may induce severe mismatches, leading to semantic ambiguity between foreground and background pixels. To address this issue, we propose a novel mask-guided proxy mining network (MPMNet), which mines a set of representative reference features (termed proxies) from support and query images to rectify foreground-background ambiguity. Specifically, to eliminate false pairwise matches caused by excessive intra-class variations, we design a mask-guided proxy mining module to adaptively learn representative proxies that can perceive visual differences between objects with different scales and shapes. Moreover, we integrate a hierarchical prior generation module and a context-aware feature enrichment module into MPMNet to obtain multi-scale information and enhance the discriminability of features. With these well-designed components and structures, our MPMNet can effectively overcome the adverse effects of false pixel matches by establishing proxy-level semantic correlations. Extensive experiments on three standard medical segmentation benchmarks demonstrate that our MPMNet significantly outperforms previous state-of-the-art methods, with a mean gain of 2.71% in DSC across all datasets. The code is available at: https://github.com/donglongzi/MPMNet.

The key that hinders the performance improvement of current camouflaged object detection (COD) models is the lack of discriminability of features at fine granularity. We solve this problem from two complementary perspectives. Firstly, complex scenes result in the discriminative feature representations of camouflaged objects being present at different scales and semantic abstraction levels. Therefore, a mechanism is needed to increase the diversity of features to integrate more information potentially beneficial for COD. Second, appearance similarity between objects and environments will inevitably lead to similarity in features. Enhancing feature diversity alone is not enough to solve the above problems. Therefore, it is necessary to give the model semantic perception capabilities to expand the subtle discrepancies between objects and environments in feature embedding. Inspired by the first point, we propose a cross-scale interaction module (CSIM) that utilizes cross-attention between different scales to enhance the diversity of feature representations. Regarding the second point, the semantic guided feature learning (SGFL) is proposed to promote the model to expand feature discrepancies through explicit supervision. Experiments on four popular COD datasets show that our method outperforms recent SOTA methods. In addition, polyp segmentation experiments show that it is also effective for other COD-like tasks.

The true label plays an important role in semi-supervised medical image segmentation (SSMIS) because it can provide the most accurate supervision information when the label is limited. The popular SSMIS method trains labeled and unlabeled data separately, and the unlabeled data cannot be directly supervised by the true label. This limits the contribution of labels to model training. Is there an interactive mechanism that can break the separation between two types of data training to maximize the utilization of true labels? Inspired by this, we propose a novel consistency learning framework based on the non-parametric distance metric of boundary-aware prototypes to alleviate this problem. This method combines CNN-based linear classification and nearest neighbor-based non-parametric classification into one framework, encouraging the two segmentation paradigms to have similar predictions for the same input. More importantly, the prototype can be clustered from both labeled and unlabeled data features so that it can be seen as a bridge for interactive training between labeled and unlabeled data. When the prototype-based prediction is supervised by the true label, the supervisory signal can simultaneously affect the feature extraction process of both data. In addition, boundary-aware prototypes can explicitly model the differences in boundaries and centers of adjacent categories, so pixel-prototype contrastive learning is introduced to further improve the discriminability of features and make them more suitable for non-parametric distance measurement. Experiments show that although our method uses a modified lightweight UNet as the backbone, it outperforms the comparison method using a 3D VNet with more parameters.