SUMMARY: Network medicine leverages the quantification of information flow within sub-cellular networks to elucidate disease etiology and comorbidity, as well as to predict drug efficacy and identify potential therapeutic targets. However, current Network Medicine toolsets often lack computationally efficient data processing pipelines that support diverse scoring functions, network distance metrics, and null models. These limitations hamper their application in large-scale molecular screening, hypothesis testing, and ensemble modeling. To address these challenges, we introduce NetMedPy, a highly efficient and versatile computational package designed for comprehensive Network Medicine analyses. AVAILABILITY AND IMPLEMENTATION: NetMedPy is an open-source Python package under an MIT license. Source code, documentation, and installation instructions can be downloaded from https://github.com/menicgiulia/NetMedPy and https://pypi.org/project/NetMedPy. The package can run on any standard desktop computer or computing cluster.

The set of controllers stabilizing a linear system is generally non-convex in the parameter space. In the case of two-parameter controller design (e.g. PI control or static output feedback with one input and two outputs), we observe however that quite often for benchmark problem instances, the set of stabilizing controllers seems to be convex. In this note we use elementary techniques from real algebraic geometry (resultants and Bezoutian matrices) to explain this phenomenon. As a byproduct, we derive a convex linear matrix inequality (LMI) formulation of two-parameter fixed-order controller design problem, when possible.