Recent advances in Large Language Models (LLMs) have opened new avenues for sequential recommendation by enabling natural language reasoning over user behavior sequences. A common approach formulates recommendation as a language modeling task, where interaction histories are transformed into prompts and user preferences are learned via supervised fine-tuning. However, these methods operate solely in the textual modality and often miss users' fine-grained interests, especially when shaped by rich visual signals such as product images or movie posters. Multimodal Large Language Models (MLLMs) offer a promising alternative by aligning text and vision in a shared semantic space. A prevalent training paradigm applies Supervised Fine-Tuning (SFT) followed by Direct Preference Optimization (DPO) to model user preferences. Yet, two core challenges remain: 1) Imbalanced sample hardness, where random negative sampling causes overfitting on easy examples and under-training on hard ones; 2) Cross-modal semantic bias, where the fixed reference model in DPO prevents the policy model from correcting modality misalignments—especially over long sequences. To address these issues, we propose a Multimodal LLM framework that integrates Hardness-aware and Noise-regularized preference optimization for Recommendation (HaNoRec). Specifically, HaNoRec dynamically adjusts optimization weights based on both the estimated hardness of each training sample and the policy model's real-time responsiveness, prioritizing harder examples. It further introduces Gaussian-perturbed distribution optimization on output logits to enhance cross-modal semantic consistency and reduce modality bias inherited from the reference model. Experiments on three benchmarks demonstrate its superiority over state-of-the-art methods.